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Related Experiment Videos

Rh sensitization after third-trimester fetal death.

C M Stedman1, R W Quinlan, J F Huddleston

  • 1Department of Obstetrics and Gynecology, University of Alabama at Birmingham.

Obstetrics and Gynecology
|March 1, 1988
PubMed
Summary
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Rh sensitization can occur after unexplained third-trimester fetal death, even with Rh immunoglobulin. Routine screening for fetomaternal hemorrhage is crucial for Rh-negative women to ensure adequate Rh prophylaxis.

Area of Science:

  • Obstetrics and Gynecology
  • Immunology
  • Perinatal Medicine

Background:

  • Rh sensitization poses a risk to Rh-negative women during pregnancy.
  • Unexplained third-trimester fetal death is a critical obstetric complication.
  • Rh immunoglobulin prophylaxis is standard to prevent Rh sensitization.

Observation:

  • Three primigravidas experienced Rh sensitization following unexplained third-trimester fetal death.
  • One patient developed sensitization post-diagnosis but pre-delivery.
  • Two patients showed anti-D antibodies in subsequent pregnancies despite postpartum Rh immunoglobulin.

Findings:

  • Unexplained third-trimester fetal death can lead to Rh sensitization.
  • Postpartum Rh immunoglobulin may not always prevent sensitization in these cases.

Related Experiment Videos

  • Fetomaternal hemorrhage is a likely mechanism for sensitization.

    • Implications:

    • Routine screening for fetomaternal hemorrhage is recommended for Rh-negative women with unexplained third-trimester fetal death.
    • Early detection of fetomaternal hemorrhage allows for timely and adequate Rh prophylaxis.
    • This approach aims to prevent Rh sensitization and subsequent hemolytic disease of the newborn.