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Updated: Jan 22, 2026

Building a Better Mosquito: Identifying the Genes Enabling Malaria and Dengue Fever Resistance in A. gambiae and A. aegypti Mosquitoes
Published on: July 4, 2007
Tying up Loose Ends in the Malaria Antigenic Variation Story
1Zhejiang University-University of Edinburgh (ZJE) Institute and Second Affiliated Hospital, Zhejiang University School of Medicine, China.
Abstract:
A recent paper (Zhang et al., PLoS Biol., 2019) shines remarkable new light onto the malaria antigenic variation story. Using CRISPR/Cas9-targeted chromosome breaks and long-read whole-genome sequencing, they followed the fate of detached subtelomeric PfEMP1/var genes and demonstrated that these initiate cascades of recombination at sites far from the original break.
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