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Protocol for the Solid-phase Synthesis of Oligomers of RNA Containing a 2'-O-thiophenylmethyl Modification and Characterization via Circular Dichroism
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Protocol for the Solid-phase Synthesis of Oligomers of RNA Containing a 2'-O-thiophenylmethyl Modification and Characterization via Circular Dichroism

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Adding dose modifications into Phase II and Phase II/III seamless trials

John Spivack1, Bin Cheng2, Bruce Levin2

  • 1Department of Environmental Medicine and Public Health, Mount Sinai Medical Center, New York, NY, USA.

Statistical Methods in Medical Research
|July 4, 2019
PubMed

Keywords:
Adaptive designdose additiondose modificationfamilywise error ratenonmonotonic dose response

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