Related Experiment Video
Updated: Jan 22, 2026

Synthesis of Biocompatible Liquid Crystal Elastomer Foams as Cell Scaffolds for 3D Spatial Cell Cultures
Published on: April 11, 2017
Quality by Design-Based Crystallization of Curcumin Using Liquid Antisolvent Precipitation: Micromeritic,
Sananda Som1, Sachin Kumar Singh1, Gopal L Khatik1
1School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, India.
Abstract:
The aim of present study was to introduce the role of quality by design to produce curcumin crystals with enhanced dissolution rate and bioavailability. The liquid antisolvent method was used to produce crystals. The crystal growth was controlled using the Box-Behnken design. The variables used in the crystallization process included the ratio of pyrocatechol to polyethylene glycol (PEG) 1500, solvent addition rate, stirring time, and stirring speed. Combination of these variables was found to yield curcumin crystals of 2.45 ± 0.56 μm size and 0.321 polydispersity index that exhibited enhanced solubility, dissolution rate, product yield, and compressibility. The optimized curcumin crystals were characterized by Fourier-transform infrared spectrophotometer (FT-IR), nuclear magnetic resonance, differential scanning calorimetry, X-ray powder diffraction, and scanning electron microscopy. The dissolution rate and oral bioavailability of optimized curcumin crystals were found to be 2.66- and 7.08-folds higher than its unprocessed form. The optimized crystals were found stable for 6 months under accelerated temperature of 40°C and 75% relative humidity as there was no significant difference observed in the crystal size and dissolution profile.
Related Concept Videos
Biopharmaceutical Factors Influencing Drug Product Design: Overview
Precipitation and Co-precipitation
Precipitation of Ions
The equation that describes the equilibrium between solid calcium carbonate and its solvated ions is:
Precipitation Reactions
Biopharmaceutics and Pharmacokinetics: Overview
Precipitation Processes

