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Updated: Jan 22, 2026

Transthoracic Speckle Tracking Echocardiography for the Quantitative Assessment of Left Ventricular Myocardial Deformation
Published on: October 20, 2016
Value of three-dimensional speckle-tracking imaging in detecting left ventricular systolic function in patients with
1Department of Cardiology, Guizhou Provincial People's Hospital, Guiyang, China.
Insights
Three-dimensional speckle-tracking imaging (3DSTI) accurately assesses left ventricular systolic function in dilated cardiomyopathy (DCM) patients. Its left ventricular ejection fraction (LVEF) measurements closely align with cardiac magnetic resonance imaging (MRI) findings.
Area of Science:
- Cardiology
- Medical Imaging
- Biomedical Engineering
Background:
- Dilated cardiomyopathy (DCM) is a significant cause of heart failure.
- Accurate assessment of left ventricular systolic function is crucial for DCM management.
- Traditional imaging methods may have limitations in quantifying cardiac function.
Purpose of the Study:
- To evaluate the diagnostic value of three-dimensional speckle-tracking imaging (3DSTI) for left ventricular systolic function in DCM patients.
- To compare 3DSTI measurements with established methods like two-dimensional echocardiography (2DE) and magnetic resonance imaging (MRI).
Main Methods:
- Thirty-one DCM patients were included in the study.
- Left ventricular volumes (LVESV, LVEDV) and ejection fraction (LVEF) were measured using 3DSTI, 2DE, and MRI.
- Left ventricular end-diastolic mass (EDmass) and index (EDmassI) were also assessed by 3DSTI and MRI.
Main Results:
- Positive correlations were observed for LVESV, LVEDV, and LVEF across all three imaging modalities.
- Significant differences in LVEF were found among the groups (3DSTI: 30.3 ± 10.6%, MRI: 26.2 ± 10.7%, P=0.04).
- 3DSTI measurements for EDmass and EDmassI were significantly lower compared to MRI (P < 0.001).
Conclusions:
- Three-dimensional speckle-tracking imaging (3DSTI) demonstrates reliable performance in assessing left ventricular systolic function in DCM.
- 3DSTI-derived LVEF values show closer agreement with MRI than with 2DE.
- 3DSTI offers a promising non-invasive tool for evaluating cardiac function in DCM.
Objective:
To explore the value of three-dimensional speckle-tracking imaging (3DSTI) in detecting left ventricular systolic function in patients with dilated cardiomyopathy (DCM).
Methods:
Totally 31 DCM patients were enrolled in this study. Left ventricular end-systolic volume (LVESV), left ventricular end-diastolic volume (LVEDV), and left ventricular ejection fraction (LVEF) were measured using the 3DSTI, two-dimensional echocardiography (2DE), and magnetic resonance imaging (MRI). Left ventricular end-diastolic mass (EDmass) and left ventricular end-diastolic mass index (LVEDmass I) were also detected by 3DSTI and MRI. The differences in these measurements were analyzed and compared.
Results:
The values of LVESV, LVEDV, and LVEF showed significantly positive correlations among 2DE group, 3DSTI group, and MRI group. The LVEF value showed significant difference among these three groups [(33.3 ± 11.1)%, (30.3 ± 10.6)%, and (26.2 ± 10.7)%; P = 0.04], whereas LVEDV and LVESV values were not significantly different (P > 0.05; respectively). Inter-group comparison showed the mean of LVEF was significantly lower in MRI group than in 2DE group (P = 0.031), whereas there was no significant difference between 2DE group and 3DSTI group and between 3DSTI group and MRI group (P > 0.05; respectively). The EDmass and EDmassI detected by 3DSTI and MRI were (143.2 ± 40.2) g vs (190.0 ± 58.3) g and (83.2 ± 21.1) g/m2 vs (110.1 ± 29.7) g/m2 (P < 0.001; respectively).
Conclusions:
The LVEF value detected by 3DSTI is closer to that detected by MRI in DCM patients.
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