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Platelet count in men with a habit of alcohol drinking
1Department of Environmental and Preventive Medicine, Hyogo College of Medicine, Nishinomiya, Japan.
Insights
This study found no significant association between habitual alcohol consumption and platelet count in a general male population. Further research is needed for heavier alcohol drinkers to confirm these findings.
Area of Science:
- Hematology
- Toxicology
- Public Health
Background:
- Alcohol consumption is known to affect platelet function and count.
- Reduced platelet counts are observed in individuals with alcohol use disorder.
- The relationship between habitual alcohol intake and platelet count in the general population requires clarification.
Purpose of the Study:
- To investigate the association between habitual alcohol consumption and platelet count in a general male population.
- To determine if varying levels of alcohol intake correlate with differences in platelet counts.
Main Methods:
- Analysis of data from 6508 men aged 30-69 undergoing health checkups.
- Utilized analysis of covariance and multivariate regression analyses.
- Controlled for variables such as age, smoking, BMI, and leukocyte count.
Main Results:
- No significant differences in mean platelet counts were observed between nondrinkers and light, moderate, or heavy alcohol drinkers.
- Odds ratios for low platelet count did not significantly differ across alcohol consumption groups compared to nondrinkers.
- Platelet count showed significant correlations with age, smoking, GGT, BMI, and leukocyte count.
Conclusions:
- Habitual alcohol drinking does not appear to be associated with platelet count in this general male population.
- Further studies with heavier drinkers are necessary to fully understand the alcohol use disorder-platelet count relationship.
Abstract:
Alcohol inhibits platelet function, and platelet count is often reduced in individuals with alcohol use disorder. However, the relation of habitual alcohol drinking with platelet count in a general population remains to be determined. The participants were 6508 men (30 ~ 69 years old) who had received annual health checkup examinations, and most of them (98.6%) were nondrinkers or drinkers with an average ethanol intake of less than 66 g per day. Relationships of platelet count with alcohol intake were investigated by using analysis of covariance and multivariate linear and logistic regression analyses. Platelet count was significantly correlated with age, smoking, γ-glutamyl transpeptidase, body mass index and leukocyte count, which were thus used as explanatory variables in the multivariate analyses. Mean platelet counts in light (<22 g of ethanol per day), moderate (≥22 and <44 g ethanol per day) and heavy (≥44 g ethanol per day) drinkers were not significantly different from that in nondrinkers. Odds ratios vs. nondrinkers of light, moderate and heavy drinkers for low platelet count (<15 x 104/μl) were not significantly different from the reference level. In conclusion, there is no association between habitual alcohol drinking and platelet count in a general population. Further studies using data for heavier drinkers are needed to confirm the relationship between alcohol use disorder and platelet count.
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