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Updated: Jan 22, 2026

En Face Preparation of Mouse Blood Vessels
Published on: May 19, 2017
Blood Vessel Proximity Shapes Cancer Cell Metabolism
Federico Virga1, Manuel Ehling2, Massimiliano Mazzone2
1Laboratory of Tumor Inflammation and Angiogenesis, Center for Cancer Biology, VIB, Leuven B3000, Belgium; Laboratory of Tumor Inflammation and Angiogenesis, Center for Cancer Biology, Department of Oncology, KU Leuven, Leuven B3000, Belgium; Molecular Biotechnology Center, University of Torino, Torino, Italy; Department of Molecular Biotechnology and Health Sciences, University of Torino, Torino, Italy.
Abstract:
Cancer cells are highly heterogeneous, and their features markedly vary within different areas of the tumor microenvironment. In this issue, Kumar et al. (2019) identified perivascular tumor cells, derived from mouse glioblastoma xenografts, as the fraction that displays the highest mTOR-dependent anabolic metabolism, aggressiveness, and resistance to therapy.
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