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Visual dysfunction in patients with idiopathic rapid eye movement sleep behavior disorder
Yuan Li1, Hui Zhang1, Wei Mao2
1Department of Neurology, Neurobiology and Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing Institute of Geriatrics, Beijing, China; Clinical Center for Parkinson's Disease, Capital Medical University, Beijing, China.
Neuroscience Letters
|July 4, 2019
Summary
Visual dysfunction is common in idiopathic rapid eye movement sleep behavior disorder (iRBD) and Parkinson
Area of Science:
- Neuroscience
- Ophthalmology
- Sleep Medicine
Background:
- Visual dysfunction is a known feature of alpha-synucleinopathies.
- Visual function is infrequently assessed in idiopathic rapid eye movement sleep behavior disorder (iRBD).
- Idiopathic RBD may precede Parkinson's disease diagnosis.
Purpose of the Study:
- To investigate comprehensive visual function in iRBD patients.
- To compare visual function between iRBD patients and Parkinson's disease (PD) patients with RBD.
- To assess the relationship between visual dysfunction and other clinical factors.
Main Methods:
- Eighty-three iRBD subjects, 52 early PD patients with RBD, and 79 healthy controls were enrolled.
- Visual functions including color discrimination and stereopsis were assessed.
- Visual illusions, hallucinations, UPDRS, cognitive tests, and Purdue Pegboard Test (PPT) were administered.
Main Results:
- Abnormal color discrimination and stereopsis were significantly higher in both iRBD and PD patients compared to controls.
- Visual dysfunction was more severe in PD patients than in iRBD patients.
- Visual changes correlated with age, cognition, and motor deficits in both groups.
Conclusions:
- Visual dysfunction is present in iRBD subjects, similar to PD patients but less severe.
- Visual dysfunction in iRBD is associated with age, cognition, and motor deficits.
- Further research is needed to determine if visual dysfunction can predict iRBD conversion to PD.
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