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Paternal exposure to bupropion affects postnatal development in the offspring
E S A M Sanches1, F Tsuzuki2, F Joinhas2
1Department of Biology, Universidade Estadual de Londrina, PR 445Km 380, 86057-970, Londrina, Parana, Brazil; and Department of General Pathology, Universidade Estadual de Londrina, PR 445Km 380, 86057-970, Londrina, Parana, Brazil.
Reproduction, Fertility, and Development
|July 5, 2019
Summary
Paternal exposure to bupropion hydrochloride (BUP) significantly altered offspring development. This antidepressant drug exposure led to long-lasting changes in physical and behavioral parameters in the offspring mice.
Area of Science:
- Neuroscience
- Developmental Biology
- Pharmacology
Background:
- Bupropion hydrochloride (BUP) is a widely prescribed antidepressant.
- Its effects on offspring development following paternal exposure are not well understood.
- Understanding paternal drug exposure impacts is crucial for reproductive health.
Purpose of the Study:
- To investigate the impact of paternal bupropion hydrochloride (BUP) exposure on the postnatal development of offspring.
- To evaluate physical, developmental, and behavioral changes in offspring.
- To determine if BUP exposure induces long-lasting effects.
Main Methods:
- Male mice were exposed to BUP (40mg/kg/day) or saline for 45 days.
- Treated males mated with drug-naïve females.
- Offspring development was assessed from postnatal day 1 to 60.
- Evaluated parameters included physical growth, reproductive development, reflexes, and behavior.
Main Results:
- Offspring of BUP-exposed males exhibited altered physical development (weight gain, body length, incisor eruption, pinna detachment).
- Changes were observed in anogenital distance, vaginal opening, and reflex development.
- Behavioral alterations, including locomotor activity and anxiety-like behavior, were noted in offspring.
Conclusions:
- Paternal exposure to bupropion hydrochloride (BUP) induces significant and long-lasting changes in offspring postnatal development.
- These findings highlight potential risks associated with paternal antidepressant use.
- Further research is needed to elucidate the mechanisms underlying these developmental alterations.
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