Related Experiment Video
Updated: Jan 22, 2026

Induction and Clinical Scoring of Chronic-Relapsing Experimental Autoimmune Encephalomyelitis
Published on: July 4, 2007
CASTLE score versus J-CTO score for the prediction of technical success in chronic total occlusion percutaneous
Andreas S Kalogeropoulos1, Osama Alsanjari, Thomas R Keeble
1Department of Cardiology, Royal Sussex County Hospital, Brighton, United Kingdom.
Insights
The EuroCTO (CASTLE) score is comparable to the J-CTO score for predicting percutaneous coronary intervention success in chronic total occlusions. However, the EuroCTO (CASTLE) score shows better prediction for more complex cases.
Area of Science:
- Cardiology
- Interventional Cardiology
Background:
- Coronary chronic total occlusions (CTOs) present a challenge for percutaneous coronary intervention (PCI).
- Predictive scoring systems aid in assessing procedural success, guiding clinical decisions.
Purpose of the Study:
- To compare the predictive efficiency of the novel EuroCTO (CASTLE) score against the established Japan CTO (J-CTO) score for CTO PCI success.
- To evaluate the performance of both scores in predicting outcomes for varying complexities of CTOs.
Main Methods:
- A retrospective analysis of 660 consecutive CTO PCI procedures was conducted.
- The Japan CTO (J-CTO) and EuroCTO (CASTLE) scores were calculated for each patient.
- Receiver operating characteristic (ROC) analysis was used to compare the discriminatory capacity of both scores.
Main Results:
- Both J-CTO and EuroCTO (CASTLE) scores demonstrated similar overall predictive capacity (AUC 0.698 vs 0.676).
- For complex CTOs (J-CTO ≥3 or EuroCTO [CASTLE] ≥4), the EuroCTO (CASTLE) score showed superior predictive ability (AUC 0.588 vs 0.473).
- Commonly used techniques included antegrade wire escalation (82%), retrograde approach (37%), and antegrade dissection re-entry (14%).
Conclusions:
- The EuroCTO (CASTLE) score is comparable to the J-CTO score in predicting CTO PCI success.
- The EuroCTO (CASTLE) score offers superior discriminatory capacity for more complex coronary chronic total occlusion interventions.
Aims:
We sought to compare the efficiency of the novel EuroCTO (CASTLE) score with the commonly used Multicentre CTO Registry in Japan (J-CTO) score in predicting procedural success of percutaneous coronary intervention (PCI) for coronary chronic total occlusions (CTOs).
Methods And Results:
We evaluated 660 consecutive CTO PCIs (mean age 66±11 years, 84% male). The mean J-CTO and EuroCTO (CASTLE) scores were 1.86±1.2 and 1.74±1.2, respectively. Antegrade wire escalation, antegrade dissection re-entry and retrograde approach were used in 82%, 14% and 37% of cases, respectively. Receiver operating characteristic analysis demonstrated equal overall discriminatory capacity between the two scores (AUC 0.698, 95% CI: 0.653-0.742, p<0.001 for J-CTO vs AUC 0.676, 95% CI: 0.627-0.725, p<0.001 for EuroCTO; AUC difference: 0.022, p=0.5). However, for more complex procedures (J-CTO ≥3 or EuroCTO [CASTLE] ≥4]), the predictive capacity of the EuroCTO (CASTLE) score appeared superior (AUC 0.588, 95% CI: 0.509-0.668, p=0.03 for EuroCTO [CASTLE] score vs AUC 0.473, 95% CI: 0.393-0.553, p=NS for the J-CTO score, AUC difference: 0.115, p=0.04).
Conclusions:
In this study, the novel EuroCTO (CASTLE) score was comparable to the J-CTO score in predicting CTO PCI outcome with a superior discriminatory capacity for the more complex cases.
Related Concept Videos
Introduction to z Scores
z scores...
Introduction to z Scores
z scores...
z Scores and Area Under the Curve
z Scores and Unusual Values
This score indicates how far a value is from the mean in terms of standard deviation. For example, if a data value has a z score of +1, the researcher can infer that the particular data value is one standard deviation above the mean. If another data...
Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT
Ecological Succession

