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Updated: Jan 22, 2026

Live Imaging of Mouse Secondary Palate Fusion
Published on: July 27, 2017
Insights
Cleft lip and cleft palate are common birth defects affecting facial anatomy. Diagnosis and management involve prenatal imaging techniques like sonography and MRI, extending through adulthood.
Area of Science:
- Craniofacial development and birth defects.
Background:
- Cleft lip (CL) and cleft palate (CP) are prevalent congenital orbitofacial anomalies.
- These conditions can arise independently, as part of a syndrome, or due to genetic and environmental influences.
- Management requires a multidisciplinary approach from prenatal diagnosis to adult care.
Purpose of the Study:
- To review the anatomical development of cleft lip and cleft palate.
- To discuss diagnostic and management imaging techniques for CL and CP.
Main Methods:
- Review of anatomical development.
- Discussion of prenatal imaging modalities including sonography and magnetic resonance imaging (MRI).
Main Results:
- CL and CP present a spectrum of severity impacting anatomical function.
- Prenatal imaging is crucial for evaluation, monitoring treatment, and identifying complications.
- Imaging techniques aid in the comprehensive management of CL and CP.
Conclusions:
- Understanding the anatomical development is key to managing CL and CP.
- Sonography and MRI are vital tools in the prenatal diagnosis and ongoing care of individuals with CL and CP.
Abstract:
Cleft lip (CL) and cleft palate (CP) are common orbitofacial birth defects that vary in severity and effect on anatomical function. They might occur as an isolated event, be associated with a syndrome, or result from genetic and environmental factors. Diagnosis and treatment of individuals begin prenatally and can extend through adulthood. Sonography and magnetic resonance imaging are used prenatally to evaluate and monitor treatment outcomes and complications associated with CL and CP. This article discusses the anatomical development of CL and CP and the imaging techniques used to diagnose and manage them.
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