Related Experiment Video
Updated: Jan 22, 2026
08:16
Partial Sciatic Nerve Ligation: A Mouse Model of Chronic Neuropathic Pain to Study the Antinociceptive Effect of Novel Therapies
Published on: October 6, 2022
7.7K
Managing Chronic Non-Malignant Pain in the Elderly: Intrathecal Therapy
Barbara Kleinmann1, Tilman Wolter2
1Interdisciplinary Pain Center, University of Freiburg, Faculty of Medicine, Breisacherstr. 64, 79106, Freiburg, Germany.
Drugs & Aging
|July 5, 2019
Summary
Intrathecal drug delivery (IDD) offers a proven method for managing chronic pain and spasticity using implanted pumps. This review focuses on IDD
Area of Science:
- Neurology
- Pain Management
- Pharmacology
Background:
- Intrathecal drug delivery (IDD) has been utilized for pain management since 1981.
- Over 300,000 IDD pumps have been implanted globally for pain and spasticity.
- The technique involves continuous intrathecal administration of medications, often opioids.
Purpose of the Study:
- To review current knowledge on intrathecal opioid therapy.
- To specifically evaluate the application and considerations of IDD in elderly patients.
- To present arguments for and against IDD in the geriatric population.
Main Methods:
- Literature review of existing studies on intrathecal drug delivery.
- Focus on studies involving elderly patients undergoing IDD.
- Analysis of evidence supporting or refuting IDD in this demographic.
Main Results:
- IDD is a well-established therapy for chronic pain and spasticity.
- Evidence regarding IDD in elderly patients is presented.
- Arguments for and against its use in this population are discussed.
Conclusions:
- Intrathecal opioid therapy is a significant treatment modality.
- Careful consideration of benefits and risks is crucial for elderly patients.
- Further research may clarify optimal IDD use in geriatric pain management.
Related Concept Videos
01:25Analgesia and Pain Management
1.5K
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
1.5K
01:29Chronic Obstructive Pulmonary Disease-V: Management
3.1K
Managing Chronic Obstructive Pulmonary Disease (COPD) involves a multifaceted approach to reduce symptoms, prevent exacerbations, improve overall health status, and slow disease progression. Key strategies include lifestyle modifications, pharmacotherapy, supportive therapies, and, in some cases, surgery. Here is an overview of the primary COPD management strategies:
Smoking Cessation
Smoking Cessation
3.1K
01:30Chronic Obstructive Pulmonary Disease-V: Nursing Management
5.1K
Nursing management of Chronic Obstructive Pulmonary Disease (COPD) is crucial for providing thorough care and support to patients. Nurses play an integral role in this process through detailed assessment, careful planning, targeted interventions, and ongoing evaluation. Here's an overview of the critical steps in nursing management for COPD.
Assessment
Assessment
5.1K
01:18Chronic Kidney Disease IV: Nursing Management
331
Nursing management is essential for preventing complications, maintaining stability, and improving patients' quality of life in chronic kidney disease (CKD). By using a structured approach, nurses help slow CKD progression and support effective patient care.1. Comprehensive patient assessmentEffective management begins with nurses reviewing the patient’s medical history, and identifying key risk factors like diabetes, hypertension, and nephrotoxic drug use. Nurses assess signs of...
331
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
655
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
655
01:20Pain
1.3K
Pain serves as a critical warning signal that alerts the body to potential or actual harm. When mechanical pressure on the skin is intense, such as from a sharp pinch, the sensation transitions from touch to pain. Similarly, extreme temperatures, like a hot pot handle, convert the sensation of heat into pain. Pain can also result from overstimulation of other senses, such as blinding light, loud noise, or the intense heat from habañero peppers. This ability to sense pain is essential for...
1.3K