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Updated: Jan 22, 2026

Evaluating Postural Control and Lower-extremity Muscle Activation in Individuals with Chronic Ankle Instability
Published on: September 18, 2020
A Novel Approach to Evaluate Brain Activation for Lower Extremity Motor Control
Dustin R Grooms1, Jed A Diekfuss2, Jonathan D Ellis3
1Ohio Musculoskeletal & Neurological Institute and Division of Athletic Training, School of Applied Health Sciences and Wellness, College of Health Sciences and Professions, Ohio University, Athens, OH.
This study found a new MRI method for lower extremity motor control is reliable for brain activity. This neuroimaging technique supports future research on motor function and therapeutic interventions.
Area of Science:
- Neuroimaging
- Motor Control
- Neuroscience
Background:
- Assessing sensorimotor region brain activity is crucial for understanding motor control.
- Developing reliable neuroimaging paradigms is essential for longitudinal studies.
Purpose of the Study:
- To evaluate the consistency of a novel, MR-safe neuroimaging paradigm for lower extremity motor control.
- To determine the reliability of eliciting sensorimotor brain activity using this paradigm.
Main Methods:
- Participants performed unilateral leg presses (ankle, knee, hip extension/flexion) in a 3T MRI scanner.
- Regions of Interest included motor cortex, somatosensory cortex, basal ganglia, and cerebellum.
- Data analyzed using mixed-effects paired t-tests and intraclass correlation coefficients.
Main Results:
- No significant differences in brain activity were found between MRI sessions (P > .05).
- Good to excellent reliability (ICC .621–.918) was observed for percent signal change and Z-scores in most sensorimotor regions.
- The left secondary somatosensory cortex showed lower reliability for percent signal change (ICC .165).
Conclusions:
- The developed lower extremity motor control paradigm is reliable for longitudinal neuroimaging.
- This task, simulating functional movements, is suitable for studying therapeutic interventions and dynamic motor function changes.
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