Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Abnormal Proliferation02:23

Abnormal Proliferation

5.1K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
5.1K
The Colonization of Land02:22

The Colonization of Land

37.4K
Changes in the environment of the early Earth drove the evolution of organisms. As prokaryotic organisms in the oceans began to photosynthesize, they produced oxygen. Eventually, oxygen saturated the oceans and entered the air, resulting in an increase in atmospheric oxygen concentration, known as the oxygen revolution approximately 2.3 billion years ago. Therefore, organisms that could use oxygen for cellular respiration had an advantage. More than 1.5 years ago, eukaryotic cells and...
37.4K
Fixed Action Patterns01:06

Fixed Action Patterns

17.5K
A fixed action pattern (FAP) is a specific, hard-wired sequence of behaviors that occurs in response to an external stimulus, called a sign stimulus. The behavior is “fixed” because it is essentially unchangeable—proceeding similarly across individuals of a species every time it occurs.
17.5K
Respiratory System Abnormal Finding I: Inspection and Percussion01:30

Respiratory System Abnormal Finding I: Inspection and Percussion

790
Respiratory system abnormalities are a significant concern in healthcare due to their potential to indicate underlying severe conditions like Chronic Obstructive Pulmonary Disease (COPD), asthma, and pneumonia. These abnormalities can often be detected through physical examination methods like inspection and percussion.
Inspection Findings
During an inspection, several findings may suggest the presence of respiratory distress or disease. Pursed-lip breathing, where exhalation is slowed by...
790
Cardiovascular System Abnormal Findings I: Inspection and Palpation01:29

Cardiovascular System Abnormal Findings I: Inspection and Palpation

835
In a cardiovascular examination, inspection and palpation are crucial for identifying abnormalities.
Abnormal findings observed during an inspection
835
Cardiovascular System Abnormal Findings II: Auscultation01:25

Cardiovascular System Abnormal Findings II: Auscultation

574
Auscultation, an essential part of a heart examination, is done using a stethoscope. It provides crucial information about heart function and possible heart problems. Due to heart problems, abnormal sounds can be heard during systole or diastole. These sounds include S3 and S4 gallops, opening snaps, systolic clicks, and murmurs.
Abnormal Heart Sounds
Gallops:
574

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Novel Class of "Super-Strained" Spiro Heterocycles: Gateway to 1-Azaspiro[3.3]heptane Derivatives, and Biological Validation.

Angewandte Chemie (International ed. in English)·2026
Same author

Focused shock wave therapy (ESWT) and electromagnetic transduction therapy (EMTT) may improve post-operative bone healing in selective foot and ankle surgeries: a case-control pilot study.

Journal of orthopaedic surgery and research·2025
Same author

Iodonitrene-Mediated Nitrogen Transfer to Alkenes for the Direct Synthesis of NH-Aziridines.

Journal of the American Chemical Society·2025
Same author

Recommendations for use of extracorporeal shockwave therapy in sports medicine: an international modified Delphi study.

British journal of sports medicine·2025
Same author

Continuous Flow Decarboxylative Monofluoroalkylation Enabled by Photoredox Catalysis.

JACS Au·2025
Same author

Shifting Lithium Amide Reactivity to the Radical Domain: Regioselective Radical C-H Functionalization of 3-Iodooxetane for the Synthesis of 1,5-Dioxaspiro[2.3]hexanes.

Angewandte Chemie (International ed. in English)·2025
Same journal

The stability and bifurcations of ecosystems within resource constraints - Dedicated to Professor Shigui Ruan on the occasion of his 60th birthday.

Mathematical biosciences·2026
Same journal

The hydra and hormetic effects in a single discrete-time overcompensation model.

Mathematical biosciences·2026
Same journal

Seasonal impacts on brucellosis transmission mediated by live sheep supply-demand dynamics.

Mathematical biosciences·2026
Same journal

Optimal controls and cost-effectiveness analysis on the transmission dynamics of early blight disease in tomatoes.

Mathematical biosciences·2026
Same journal

Temperature-dependent dynamics and allee effect thresholds mediate fourfold cusp stability in biological control of invasive vectors.

Mathematical biosciences·2026
Same journal

Dynamics of a stochastic tumor-immune interaction system with an Ornstein-Uhlenbeck process.

Mathematical biosciences·2026
See all related articles

Related Experiment Video

Updated: Jan 22, 2026

Generation of Murine Primary Colon Epithelial Monolayers from Intestinal Crypts
06:57

Generation of Murine Primary Colon Epithelial Monolayers from Intestinal Crypts

Published on: February 6, 2021

8.5K

Biomathematical model for simulating abnormal orifice patterns in colonic crypts.

Isabel N Figueiredo1, Carlos Leal1, Giuseppe Romanazzi2

  • 1CMUC, Department of Mathematics, Faculty of Sciences and Technology, University of Coimbra, Coimbra, Portugal.

Mathematical Biosciences
|July 5, 2019
PubMed
Summary
This summary is machine-generated.

This study models colonic crypt orifice shape changes due to abnormal cell proliferation. Mathematical simulations show excess cell growth can cause anomalous patterns seen in colonoscopy, aiding cancer prevention.

Keywords:
Colonic cryptConvection-diffusionViscoelasticity

More Related Videos

Three-Dimensional Culture of Murine Colonic Crypts to Study Intestinal Stem Cell Function Ex Vivo
07:46

Three-Dimensional Culture of Murine Colonic Crypts to Study Intestinal Stem Cell Function Ex Vivo

Published on: October 11, 2022

4.0K
Quantification of Colonic Stem Cell Mutations
07:53

Quantification of Colonic Stem Cell Mutations

Published on: September 25, 2015

7.0K

Related Experiment Videos

Last Updated: Jan 22, 2026

Generation of Murine Primary Colon Epithelial Monolayers from Intestinal Crypts
06:57

Generation of Murine Primary Colon Epithelial Monolayers from Intestinal Crypts

Published on: February 6, 2021

8.5K
Three-Dimensional Culture of Murine Colonic Crypts to Study Intestinal Stem Cell Function Ex Vivo
07:46

Three-Dimensional Culture of Murine Colonic Crypts to Study Intestinal Stem Cell Function Ex Vivo

Published on: October 11, 2022

4.0K
Quantification of Colonic Stem Cell Mutations
07:53

Quantification of Colonic Stem Cell Mutations

Published on: September 25, 2015

7.0K

Area of Science:

  • Biomathematics
  • Computational Biology
  • Gastroenterology

Background:

  • Colonic polyps are crucial in colon cancer diagnosis and prevention.
  • Histopathology correlates with colonic crypt orifice shapes.
  • Understanding crypt morphology aids in detecting cancerous changes.

Purpose of the Study:

  • To develop a biomathematical model simulating anomalous colonic crypt orifice shapes.
  • To link abnormal cell proliferation to changes in crypt orifice morphology.
  • To provide a computational tool for analyzing colonoscopy images.

Main Methods:

  • Coupling a mechanical (elastic/viscoelastic) model with a convection-diffusion model.
  • Formulating the model in a 2D setting to mimic colonoscopy views.
  • Developing a numerical procedure for solving the model.

Main Results:

  • Simulations demonstrate that excess cell proliferation induces pressure changes.
  • These pressure variations cause mechanical forces leading to altered crypt orifice shapes.
  • The model successfully replicates anomalous patterns observed in vivo.

Conclusions:

  • The biomathematical model effectively simulates crypt orifice deformation caused by abnormal cell proliferation.
  • This approach can help identify early signs of colonic abnormalities.
  • The findings contribute to improved colon cancer diagnosis and prevention strategies.