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Tetrabromobisphenol A (TBBPA) inhibits denitrification via regulating carbon metabolism to decrease electron donation

Rui Wan1, Lei Wang2, Yinguang Chen3

  • 1Anhui Provincial Engineering Laboratory of Water and Soil Pollution Control and Remediation, School of Environmental Science and Engineering, Anhui Normal University, 189 South of Jiuhua Road, Wuhu, Anhui, 241002, China; School of Chemical and Biomedical Engineering, Nanyang Technological University, 62 Nanyang Drive, 637459, Singapore.

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Tetrabromobisphenol A (TBBPA) significantly impairs nitrogen removal by inhibiting key bacterial metabolic pathways and reducing microbial populations. This leads to increased nitrogen intermediates and nitrous oxide emissions, impacting environmental health.

Keywords:
DenitrificationElectron transportFlame retardantsNADHTBBPA

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Area of Science:

  • Environmental Science
  • Microbiology
  • Environmental Chemistry

Background:

  • Brominated flame retardants (BFRs) pose environmental risks.
  • The impact of TBBPA on microbial denitrification is not well understood.
  • Denitrification is crucial for nitrogen cycling, eutrophication control, and greenhouse gas emissions.

Purpose of the Study:

  • To investigate the effects of TBBPA on microbial denitrification.
  • To elucidate the underlying mechanisms of TBBPA's impact on denitrifiers.
  • To assess the consequences for nitrogen removal and environmental quality.

Main Methods:

  • Microbial assays to measure nitrogen removal efficiency and intermediate accumulation.
  • Analysis of bacterial populations and denitrifying capabilities.
  • Gene expression analysis of key metabolic enzymes.

Main Results:

  • 1.0 mg/L TBBPA reduced nitrogen removal by 81.7% and increased NO2--N and N2O accumulation.
  • TBBPA inhibited glycolysis and pentose phosphate pathways while promoting the glyoxylate bypass.
  • Reduced NADH generation and increased reactive nitrogen species (RNS) led to decreased bacterial proliferation and increased apoptosis.

Conclusions:

  • TBBPA significantly disrupts microbial denitrification processes.
  • Metabolic inhibition and oxidative stress contribute to reduced denitrifier activity and population.
  • TBBPA poses a substantial risk to nitrogen cycling and environmental quality.