Studying metabolic flux adaptations in cancer through integrated experimental-computational approaches

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...

DefinitionComputed Tomography (CT) of the genitourinary (GU) tract is a non-invasive imaging modality that utilizes X-rays and computer processing to generate detailed cross-sectional images of the urinary system, encompassing the kidneys, ureters, bladder, and adjacent structures such as the adrenal glands.PurposeCT scans of the GU tract serve several diagnostic and therapeutic purposes, including:Diagnosis of Urinary Tract Diseases: Detects kidney stones, tumors, cysts, and congenital...

Overview

The concept of flux describes how much of something goes through a given area. More formally, it is the dot product of a vector field within an area. For a better understanding, consider an open rectangular surface with a small area that is placed in a uniform electric field. The larger the area, the more field lines go through it and, hence, the greater the flux; similarly, the stronger the electric field (represented by a greater density of lines), the greater the flux. On the other hand, if...

The magnetic flux measures the number of magnetic field lines passing through a given surface area. The SI unit for magnetic flux is the weber (Wb). Magnetic flux is a scalar quantity. It depends on three factors: the strength of the magnetic field B, the area through which the field lines pass, and the relative orientation of the field with the surface area.
Suppose a surface is divided into elements of area dA. For each element, the component of the magnetic field that is normal to the...

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...