[The Effect of Ninjinyoeito for Patients Undergoing Chemotherapy]

The effect of Ninjinyoeito on reducing adverse reactions during chemotherapy for gastrointestinalcancer was investigated. Patients suffering from "fatigue"after undergoing chemotherapy for gastrointestinalcancer between January and April 2017 were investigated. The subjects were divided into two groups; Ninjinyoeito(treatment group)and a controlgroup. Patients were examined at the initiation of treatment and 12 weeks after treatment, and then subsequently evaluated in the form of an interview sheet to establish physicalsymptoms and CTCAE v4.0. Treatment and controlgroup comprised 24 and 9 cases, respectively. Cases where both the score of "fatigue"and proportion of patients with a score of over 2 improved were found only in the treatment group. Although numbness of hands and feet deteriorated, there was no significant difference in the proportion of patients with a score of over 2. In the assessment of CTCAE v4.0, only cases in the treatment group showed improvement of "fatigue"and proportion of patients with a score of over 2 before and after treatment. Although there was no significant difference in "peripheralneuropathy"between the two groups, patients with a score of over 2 in the treatment group showed an improvement. Our results show Ninjinyoeito helps to alleviate the symptoms of patients who had undergone chemotherapy for gastrointestinalcancer. Thus, treatment with Ninjinyoeito may contribute to enhancing the continuity of medicalcare and improving the prognosis of chemotherapy.