Related Experiment Videos
Coronary involvement in patients with Behçet's disease
Hua Chen1,2, Yuehua Zhang1,2,3, Chaoran Li1,2
1Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, 1 Shuaifuyuan, Dongcheng District, Beijing, 100730, China.
Clinical Rheumatology
|July 6, 2019
Summary
Coronary involvement in Behçet
Area of Science:
- Cardiology
- Rheumatology
- Vascular Medicine
Background:
- Behçet's disease (BD) is a rare multisystemic inflammatory disorder.
- Coronary artery involvement is an uncommon but serious complication of BD.
- Understanding risk factors is crucial for early detection and management.
Purpose of the Study:
- To identify clinical features of coronary involvement in BD patients.
- To determine potential risk factors associated with coronary artery complications in BD.
- To analyze demographic, clinical, and laboratory data in BD patients with and without coronary involvement.
Main Methods:
- Retrospective case-control study of 476 BD patients (2000-2016).
- Coronary involvement assessed via coronary angiography and/or CT angiography.
- Comparison of demographic, clinical, and laboratory data between groups.
Main Results:
- Coronary involvement occurred in 4.0% of BD patients, predominantly males.
- Common manifestations included stenosis, aneurysm, and occlusion, often multivessel.
- Pathergy reaction, elevated ESR and CRP, male gender, skin lesions, and extra-cardiac vasculitis were associated with coronary involvement.
Conclusions:
- Coronary involvement in BD is rare, male-predominant, and characterized by aneurysms and multivessel disease.
- Pathergy reaction is identified as an independent risk factor for coronary involvement in BD.
- Elevated erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) are frequent findings.