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The Relationship between Plasma Soluble Receptor for Advanced Glycation End Products and Coronary Artery Disease

Xiangming Wang1, Tingting Xu1, Deeraj Mungun1

  • 1Department of Geriatric Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Disease Markers
|July 6, 2019
PubMed

Insights

Elevated levels of soluble receptor for advanced glycation end products (sRAGE) and S100A12 indicate acute coronary syndrome (ACS). Their combined measurement may predict severe coronary artery disease (CAD) and its inflammatory processes.

Area of Science:

  • Cardiology
  • Biochemistry
  • Inflammation Research

Background:

  • Inflammation plays a key role in coronary artery disease (CAD) development.
  • The receptor for advanced glycation end products (RAGE) is implicated in CAD, but sRAGE and S100A12 expression data in CAD patients are inconsistent.
  • This study investigates sRAGE and S100A12 expression and their relationship across different CAD severity levels.

Purpose of the Study:

  • To determine plasma levels of sRAGE and S100A12 in patients with varying degrees of CAD.
  • To explore the correlation between sRAGE, S100A12, and CAD severity.
  • To evaluate the potential of sRAGE and S100A12 as biomarkers for severe CAD.

Main Methods:

  • 259 patients were categorized into control, nonobstructive coronary atherosclerosis (NOCA), stable angina (SAP), and acute coronary syndrome (ACS) groups.
  • Peripheral arterial blood was collected during coronary angiography (CAG) or percutaneous coronary intervention (PCI).
  • Plasma sRAGE and S100A12 levels were quantified using ELISA, and CAD severity was assessed by the SYNTAX score.

Main Results:

  • sRAGE levels were significantly higher in the ACS group compared to control, NOCA, and SAP groups.
  • S100A12 levels were significantly elevated in the ACS group versus control and NOCA groups.
  • Elevated sRAGE correlated positively with the SYNTAX score, and the combination of sRAGE and S100A12 showed good predictive performance for high-risk CAD.

Conclusions:

  • Plasma sRAGE and S100A12 levels increase in patients with acute coronary syndrome (ACS).
  • Elevated sRAGE is potentially linked to CAD severity and inflammation.
  • The combined use of sRAGE and S100A12 may serve as a predictor for severe coronary heart disease.
Abstract

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