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A Novel Digital Platform for a Monitored Home-based Cardiac Rehabilitation Program
Published on: April 19, 2019
Cost-Effectiveness of Cardiac Rehabilitation in Patients with Coronary Artery Disease: A Meta-Analysis
Tomoyuki Takura1, Nozomi Ebata-Kogure2, Yoichi Goto3
1Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan.
Insights
Cardiac rehabilitation (CR) significantly improves quality-adjusted life years (QALYs) for coronary artery disease patients. This meta-analysis indicates CR is a potentially cost-effective therapy, offering improved cost per QALY compared to usual care.
Area of Science:
- Cardiology
- Health Economics
Background:
- Rising global medical costs for cardiovascular disease necessitate cost-effective treatments.
- Economic evaluations of cardiac rehabilitation (CR) are limited, particularly meta-analyses comparing costs and patient outcomes.
Purpose of the Study:
- To conduct a meta-analysis evaluating the cost-effectiveness of cardiac rehabilitation (CR) versus usual care (UC) for coronary artery disease (CAD) patients.
- To assess medical costs, quality-adjusted life year (QALY), and life year (LY) outcomes associated with CR.
Main Methods:
- Meta-analysis of 5 studies involving 122,485 patients with coronary artery disease (CAD), including convalescent and comprehensive CR populations.
- Evaluation of medical costs, QALY, LY, and incremental cost-utility ratios (ICURs).
- Comparison of CR versus usual care (UC) using risk ratio (RR) and standardized mean difference (SMD).
Main Results:
- CR significantly improved QALY (SMD: -1.78) compared to UC.
- While CR had slightly higher medical costs (SMD: 0.02), it significantly improved cost per QALY (SMD: -0.31).
- ICURs indicated that CR was dominant (cheaper and more effective) in some cases and cost-effective (<$50,000 USD/QALY) in others.
Conclusions:
- Cardiac rehabilitation (CR) demonstrates potential cost-effectiveness for patients with coronary artery disease.
- Despite data limitations, CR offers improved QALY and favorable cost-effectiveness ratios compared to usual care.
Background:
Medical costs associated with cardiovascular disease are increasing considerably worldwide; therefore, an efficacious, cost-effective therapy which allows the effective use of medical resources is vital. There have been few economic evaluations of cardiac rehabilitation (CR), especially meta-analyses of medical cost versus patient outcome.
Methods:
The target population in this meta-analysis included convalescent and comprehensive CR patients with coronary artery disease (CAD), the status most commonly observed postmyocardial infarction (MI). Here, we evaluated medical costs, quality-adjusted life year (QALY), cost-effectiveness, mortality, and life year (LY). Regarding cost-effectiveness analysis, we analyzed medical costs per QALY, medical costs per LY, and the incremental cost-utility ratio (ICUR). We then examined the differences in effects for the 2 treatment arms (CR vs. usual care (UC)) using the risk ratio (RR) and standardized mean difference (SMD).
Results:
We reviewed 59 studies and identified 5 studies that matched our selection criteria. In total, 122,485 patients were included in the analysis. Meta-analysis results revealed that the CR arm significantly improved QALY (SMD: -1.78; 95% confidence interval (CI): -2.69, -0.87) compared with UC. Although medical costs tended to be higher in the CR arm compared to the UC arm (SMD: 0.02; 95% CI: -0.08, 0.13), cost/QALY was significantly improved in the CR arm compared with the UC arm (SMD: -0.31; 95% CI: -0.53, -0.09). The ICURs for the studies (4 RCTs and 1 model analysis) were as follows: -48,327.6 USD/QALY; -5,193.8 USD/QALY (dominant, CR is cheaper and more effective than UC); and 4,048.0 USD/QALY, 17,209.4 USD/QALY, and 26,888.7 USD/QALY (<50,000 USD/QALY, CR is costlier but more effective than UC), respectively. Therefore, there were 2 dominant and 3 effective results.
Conclusions:
While there are some limitations, primarily regarding data sources, our results suggest that CR is potentially cost-effective.
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