Related Experiment Video
Updated: Jan 22, 2026
08:36
Separation of Mouse Embryonic Facial Ectoderm and Mesenchyme
Published on: April 12, 2013
11.5K
Sorafenib-induced Facial Acneiform Eruption
Maria C Mijares1, Adam S Aldahan2, Hector H Gonzalez1
1Internal Medicine, Florida Atlantic University Charles E. Schmidt College of Medicine, Boca Raton, USA.
Cureus
|July 6, 2019
Summary
Sorafenib, a cancer drug, can cause rare acne-like skin reactions even at low doses. This case highlights a severe facial eruption in a patient with liver cancer, suggesting a need for awareness of this unusual side effect.
Area of Science:
- Oncology
- Dermatology
- Pharmacology
Background:
- Sorafenib is a multikinase inhibitor used for hepatocellular carcinoma.
- Common sorafenib side effects include alopecia and hand-foot skin reactions.
- Acneiform eruptions are rare, typically associated with high sorafenib doses.
Observation:
- A patient developed a severe facial acneiform eruption while on low-dose sorafenib.
- This occurred in the absence of other sorafenib-related cutaneous adverse events.
- Topical treatments provided only minimal improvement.
Findings:
- Facial acneiform eruption is a rare sorafenib adverse event, previously undescribed at low doses.
- Acneiform papules without other skin issues are unusual.
- The exact mechanism is unclear, possibly involving EGFR inhibition or eccrine gland effects.
Implications:
- This case expands the known spectrum of sorafenib-induced dermatologic toxicity.
- Clinicians should consider acneiform eruptions in patients on low-dose sorafenib.
- Management may require adjusting treatment or considering alternative therapies if severe.
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