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Induction of Alloantigen-specific Anergy in Human Peripheral Blood Mononuclear Cells by Alloantigen Stimulation with Co-stimulatory Signal Blockade
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Antithymocyte globulin in the treatment of gold induced severe aplastic anemia

J M Alvaro-Gracia1, S Castañeda-Sanz, R Arranz

  • 1Rheumatology Section, Hospital de la Princesa, Universidad Autónoma, Madrid, Spain.

The Journal of Rheumatology
|January 1, 1988
PubMed

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Hybridoma technology is used for the large-scale production of monoclonal antibodies. Monoclonal antibodies bind to only a single antigenic determinant or epitope. Such antibodies are used in research, diagnostics, and disease therapy. The hybridoma technology established in 1975 by Georges Köhler and Cesar Milstein was awarded the Nobel Prize in Medicine in 1984 for revolutionizing research and therapy.
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Commonly used fusion techniques — electroporation, polyethylene glycol...