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Navigated non-contact fluorescence tomography.

M J Daly1,2, B C Wilson2,3,4, J C Irish1,2,5,6

  • 1Institute of Medical Science, University of Toronto, Toronto, ON, Canada.

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|July 6, 2019
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Summary
This summary is machine-generated.

A new non-contact diffuse optical tomography (DOT) system uses surgical navigation for real-time imaging. This approach enhances precision for surgical guidance, particularly in head and neck cancer procedures.

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Area of Science:

  • Biomedical Optics
  • Medical Imaging
  • Surgical Navigation

Background:

  • Diffuse Optical Tomography (DOT) traditionally requires physical contact, limiting its use for real-time intraoperative imaging.
  • Accurate localization of optical sources and detectors is crucial for reconstructing subsurface tissue properties.

Purpose of the Study:

  • To develop and validate a non-contact DOT system integrated with surgical navigation for on-demand image updates.
  • To improve the accuracy and precision of optical tomography in a surgical context.

Main Methods:

  • A stereoscopic optical tracker was used for real-time localization of laser and camera components.
  • Combined camera calibration and tracking data determined intrinsic camera parameters and spatial transforms.
  • A multi-stage model converted camera data to surface flux, accounting for various optical and electronic factors.
  • Finite-element DOT implementation projected source/detector positions onto a tissue mesh.

Main Results:

  • Mean target registration errors for calibration were below 1 mm.
  • Surface flux measurements in phantoms showed low mean errors (3.1% reflectance, 4.4% fluorescence) compared to diffusion theory.
  • Inverse reconstructions accurately localized subsurface targets with an average centroid error of 0.44 mm.

Conclusions:

  • The developed non-contact DOT system provides accurate, real-time imaging guidance.
  • This technology shows promise for clinical applications in head and neck surgery, including tumor resection and lymph node mapping.