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Updated: Jan 22, 2026
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Isolation and Cultivation of Mandibular Bone Marrow Mesenchymal Stem Cells in Rats
Published on: August 25, 2020
5.9K
Mandibular bone is protected against microarchitectural alterations and bone marrow adipose conversion in
Xavier Coutel1, Jérôme Delattre1, Pierre Marchandise1
1Univ. Lille, Univ. Littoral Côte d'Opale, CHU Lille, EA 4490 - PMOI, F-59000 Lille, France.
Bone
|July 6, 2019
Summary
Bone marrow adipose tissue (BMAT) plays a role in osteoporosis. Ovariectomy caused less bone loss in rat mandibles than tibias, with lower BMAT content and different distribution, suggesting specific mandibular resilience.
Area of Science:
- Biomedical Sciences
- Osteoporosis Research
- Skeletal Biology
Background:
- Osteoporosis causes bone loss and microarchitectural changes, with controversial involvement in the jaw.
- Bone marrow adipose tissue (BMAT) is implicated in bone metabolism, aging, and osteoporosis.
Purpose of the Study:
- To investigate correlations between mandibular bone microarchitecture, BMAT content, and its spatial distribution.
- To assess the impact of aging and ovariectomy (OVX) on mandibular bone and BMAT in a rat model.
Main Methods:
- Long-term follow-up study in mature rats.
- Analysis of mandibular and tibial bone microarchitecture and BMAT content and distribution.
- Comparison between aging and OVX groups.
Main Results:
- No age-related changes in mandibular microarchitecture or BMAT were observed.
- OVX-induced bone loss was significantly lower in the mandible (3-fold) compared to the tibia, primarily affecting alveolar bone.
- Mandibular BMAT content was lower and located further from bone surfaces compared to the tibia, with delayed increase post-OVX.
Conclusions:
- The mandible exhibits a specific, resilient response to OVX compared to the tibia, with fewer microarchitectural alterations.
- Mandibular BMAT content and distribution differ significantly from the tibia in the context of OVX.
- Oral functions might offer a protective effect on mandibular BMAT conversion following OVX.
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