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Updated: Jan 22, 2026

Characterization of G Protein-coupled Receptors by a Fluorescence-based Calcium Mobilization Assay
Published on: July 28, 2014
Microcalcifications, calcium-sensing receptor, and cancer.
Julien Anract1, Manon Baures2, Nicolas Barry Delongchamps1
1INSERM Unit 1151, Institut Necker Enfants Malades (INEM), Université Paris Descartes, Paris 75014, France; Urology Department, Hôpital Cochin, Assistance Publique Hôpitaux de Paris, Paris 75014, France.
This review explores the connection between calcium stones in the prostate, inflammation, and calcium sensing receptor (CaSR) function. It discusses their role in prostate cancer patients, highlighting potential links with calcium supplementation.
Area of Science:
- Urology
- Nephrology
- Oncology
Background:
- Calcium stones (calculi) form in tissues due to high local calcium concentrations.
- Prostatic calculi are linked to benign prostatic hyperplasia and chronic inflammation, often involving urine reflux.
- Elevated calcium levels at infection sites may recruit inflammatory cells.
Purpose of the Study:
- To review the relationship between calcium calculi, inflammation, and calcium sensing receptor (CaSR) in prostate cancer.
- To explore the role of CaSR in inflammatory cell recruitment.
- To discuss implications for calcium supplementation in prostate cancer patients.
Main Methods:
- Literature review of studies on prostatic calculi, inflammation, and CaSR.
- Analysis of the role of cytokines like IL-6 and calcium concentrations on CaSR.
- Synthesis of findings related to prostate cancer patients.
Main Results:
- High calcium concentrations and cytokines like IL-6 can increase CaSR expression and activity.
- CaSR may be a key mediator in recruiting inflammatory cells to the prostate.
- Potential links exist between calcium calculi, inflammation, and prostate cancer progression.
Conclusions:
- The interplay between calcium, inflammation, and CaSR is significant in the prostate.
- Understanding these mechanisms may inform therapeutic strategies, including calcium supplementation, in prostate cancer care.
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