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Updated: Jan 22, 2026

Chronic Salmonella Infected Mouse Model
Published on: May 31, 2010
Potential Involvement of Salmonella Infection in Autoimmunity
Zhanna Ktsoyan1, Lyudmila Budaghyan2, Marina Agababova2
1Institute of Molecular Biology, National Academy of Sciences, Yerevan 0014, Armenia.
Abstract:
In this work, we investigated the potential effects of nontyphoidal Salmonella infection on autoantibody (AA) formation. The titer and profiles of autoantibodies in the sera of patients with acute salmonellosis due to Salmonella enterica serovar Typhimurium (S. Typhimurium) or Salmonella enterica serovar Enteritidis (S. Enteritidis) infection, as well as in convalescent patients, were determined with indirect immunofluorescence. A significant increase of autoantibodies in acute diseases caused by both serotypes of Salmonella and during post infection by S. Enteritidis was detected. Antibody profile analysis by multivariate statistics revealed that this increase was non-specific and was not dependent on the infectious agent or disease stage. The results obtained suggest that nontyphoidal Salmonella infection contributes to the generation of autoantibodies and may play a role in autoimmune disease.
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