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Should Methotrexate Have Any Place in the Treatment of Psoriatic Arthritis?
1Oxford University Clinical Academic Graduate School, University of Oxford, John Radcliffe Hospital (Main Hospital), Room 3A31, The Cairns Library IT Corridor, Level 3, Oxford OX3 9DU, UK.
Abstract:
Methotrexate (MTX) is widely used in the treatment of psoriatic arthritis (PsA), despite the evidence base for this being limited. This narrative review summarizes the evidence to date of using MTX within different domains of psoriatic disease, including peripheral arthritis, axial disease, dactylitis, enthesitis, psoriasis, and nail disease. We also explore the role of MTX in combination therapy with tumor necrosis factor inhibitors, in addition to its safety and tolerability, to answer the question: should methotrexate have any place in the treatment of psoriatic arthritis?
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