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Genomics02:02

Genomics

39.8K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
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Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

36.9K
Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
36.9K
Design Example: Alignment of a Road Line Using GIS01:17

Design Example: Alignment of a Road Line Using GIS

339
The alignment of a road line using Geographic Information Systems (GIS) is a critical process in civil engineering, combining advanced technology with practical decision-making. This methodology begins with the collection of geospatial data, including information on land cover, geomorphology, drainage patterns, slope, and contour details. Such data is typically acquired through satellite imagery and GIS tools, offering a comprehensive understanding of the terrain.Once the data is gathered, it...
339
Genome Size and the Evolution of New Genes03:21

Genome Size and the Evolution of New Genes

9.0K
While every living organism has a genome of some kind (be it RNA, or DNA), there is considerable variation in the sizes of these blueprints. One major factor that impacts genome size is whether the organism is prokaryotic or eukaryotic. In prokaryotes, the genome contains little to no non-coding sequence, such that genes are tightly clustered in groups or operons sequentially along the chromosome. Conversely, the genes in eukaryotes are punctuated by long stretches of non-coding sequence.
9.0K
Comparing Mitochondrial, Chloroplast, and Prokaryotic Genomes02:16

Comparing Mitochondrial, Chloroplast, and Prokaryotic Genomes

15.3K
The present-day mitochondrial and chloroplast genomes have retained some of the characteristics of their ancestral prokaryotes and also have acquired new attributes during their evolution within eukaryotic cells. Like prokaryotic genomes, mitochondrial and chloroplast genomes neither bind with histone-like proteins nor show complex packaging into chromosome-like structures, as observed in eukaryotes. Unlike mitotic cell divisions observed in eukaryotic cells, mitochondria and chloroplasts...
15.3K
Impression Management Techniques III: Aligning Actions01:29

Impression Management Techniques III: Aligning Actions

127
Aligning actions are communicative strategies individuals employ to maintain social harmony and preserve personal identity in the face of potential disruptions to social norms. These actions are particularly important in managing social impressions when one's behavior might be seen as inappropriate, incompetent, or morally questionable.Types of Aligning ActionsThe three principal types of aligning actions are disclaimers, accounts, and apologies.DisclaimersDisclaimers are preventive; they are...
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Updated: Jan 22, 2026

Ultra-long Read Sequencing for Whole Genomic DNA Analysis
10:34

Ultra-long Read Sequencing for Whole Genomic DNA Analysis

Published on: March 15, 2019

23.9K

Whole-Genome Alignment.

Colin N Dewey1

  • 1Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, WI, USA. colin.dewey@wisc.edu.

Methods in Molecular Biology (Clifton, N.J.)
|July 7, 2019
PubMed
Summary
This summary is machine-generated.

Whole-genome alignment (WGA) predicts evolutionary links between genomes. This summary overviews WGA methods, their significance, and challenges in evaluating these complex genomic analyses.

Keywords:
Comparative genomicsGenome evolutionHomology mapSequence alignmentToporthologyWhole-genome alignment

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Area of Science:

  • Genomics
  • Bioinformatics
  • Computational Biology

Background:

  • Whole-genome alignment (WGA) infers evolutionary relationships at the nucleotide level between multiple genomes.
  • WGA integrates sequence alignment and gene orthology prediction, presenting significant computational challenges due to genome scale and complexity.

Purpose of the Study:

  • To define the meaning and significance of whole-genome alignment.
  • To provide an overview of existing WGA methodologies.
  • To examine challenges in evaluating whole-genome alignment tools and identify future research directions.

Main Methods:

  • Review and synthesis of current whole-genome alignment techniques.
  • Discussion of comparative genomics principles relevant to WGA.
  • Analysis of evaluation metrics and benchmarks for WGA performance.

Main Results:

  • WGAs are crucial for genome-wide analyses including phylogenetic inference, annotation, and function prediction.
  • Numerous WGA methods have been developed, each with specific strengths and limitations.
  • Evaluating WGA performance presents ongoing challenges, requiring robust benchmarks and metrics.

Conclusions:

  • Whole-genome alignment is a vital yet challenging field in bioinformatics.
  • Continued development of WGA methods and evaluation strategies is essential for advancing genomic research.
  • Addressing methodological challenges will maximize the utility of extensive genomic data.