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Updated: Jan 22, 2026

Separation and Fractionation of Culture Filtrate Proteins (CFPs) from Mycobacterium tuberculosis
Published on: July 11, 2025
Defining threshold values in microscopic examination and qPCR for optimal performance of line probe assays for
Karoline Wagner1, Benjamin Preiswerk1, Peter M Keller1
1Institute of Medical Microbiology and National Reference Center for Mycobacteria, University of Zurich, Gloriastrasse 28/30, 8006 Zurich, Switzerland.
Abstract:
Line probe assays enable rapid detection of drug-resistant Mycobacterium tuberculosis directly from clinical specimens. This study shows that defining threshold values in microscopic examination or PCR detection of M. tuberculosis optimizes line probe assay efficiency, thereby avoiding costs and loss of time due to unnecessary molecular testing.
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