Management of Multiple Secreting Paragangliomas in a Succinate Dehydrogenase Subunit D (SDHD) Variant Carrier
Johannes A Rijken1, Berry de Vos1, C René Leemans1
1Department of Otolaryngology/Head and Neck Surgery, Amsterdam University Medical Center, Vrije Universiteit, Amsterdam, the Netherlands.
Abstract:
Management of functional intrathoracic sympathetic paragangliomas in succinate dehydrogenase subunit D (SDHD) mutation carriers is challenging, and there is no uniform guideline for treatment to date. The risks of potential malignant behavior and long-term cardiovascular morbidity have to be weighed against the risks of treatment complications. We report the multidisciplinary and shared decision-making approach that resulted in successful surgical removal of 3 paragangliomas in a SDHD mutation carrier.
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