Related Experiment Video

Updated: Jan 22, 2026

Evaluation of Fluid Overload by Bioelectrical Impedance Vectorial Analysis
07:17

Evaluation of Fluid Overload by Bioelectrical Impedance Vectorial Analysis

Published on: August 17, 2022

3.2K

Clinical Outcomes Associated with Fluid Overload in Critically Ill Pediatric Patients

Ahmed El-Nawawy1, Azza A Moustafa1, Manal A M Antonios1

  • 1Department of Pediatrics, Faculty of Medicine, El-Shatby Hospital, Alexandria University, Alexandria, Egypt.

Journal of Tropical Pediatrics
|July 8, 2019
PubMed

Insights

Fluid overload (FO) is linked to mortality in pediatric ICUs. A threshold of 7% FO suggests a critical level, indicating that conservative fluid management may improve outcomes for critically ill children.

Area of Science:

  • Pediatric Critical Care Medicine
  • Intensive Care Unit (ICU) Management
  • Fluid Balance Monitoring

Background:

  • Fluid overload (FO) is a significant concern in intensive care units (ICUs), potentially impacting patient morbidity and mortality.
  • The precise relationship and critical threshold of FO related to mortality require further investigation.

Purpose of the Study:

  • To assess the effect of fluid overload on mortality in a pediatric ICU.
  • To determine a critical threshold of fluid overload associated with increased mortality risk.

Main Methods:

  • A prospective observational study conducted in a pediatric ICU.
  • Recruitment of 203 patients admitted over 12 months with a length of stay exceeding 48 hours.
  • Monitoring and analysis of fluid overload levels in relation to patient outcomes.

Main Results:

  • Fluid overload was found to be statistically related to mortality (p=0.025).
  • A fluid overload cutoff level of 7% was identified as a significant discriminator of death (AUC = 0.655, p=0.0008).
  • Kaplan-Meier analysis revealed significantly different survival rates for patients with FO above and below 7% (p=0.002).

Conclusions:

  • Accurate and frequent monitoring of fluid overload is essential for critically ill patients.
  • A threshold of 7% fluid overload suggests a point beyond which conservative fluid administration may enhance patient outcomes.
Abstract

Keywords:
fluid overloadintravenous fluidmorbiditymortalitythreshold of fluid overload

More Related Videos

Manual Muscle Testing: A Method of Measuring Extremity Muscle Strength Applied to Critically Ill Patients09:44

Manual Muscle Testing: A Method of Measuring Extremity Muscle Strength Applied to Critically Ill Patients

Published on: April 12, 2011

83.0K
Author Spotlight: Exploring Venous Waveforms in Porcine Models to Tackle Volume Overload in Medicine06:09

Author Spotlight: Exploring Venous Waveforms in Porcine Models to Tackle Volume Overload in Medicine

Published on: January 12, 2024

997

Related Concept Videos

Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
214
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
269
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
198
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
260
Critical Region, Critical Values and Significance Level01:16

Critical Region, Critical Values and Significance Level

The critical region, critical value, and significance level are interdependent concepts crucial in hypothesis testing.
In hypothesis testing, a sample statistic is converted to a test statistic using z, t, or chi-square distribution. A critical region is an area under the curve in  probability distributions demarcated by the critical value. When the test statistic falls in this region, it suggests that the null hypothesis must be rejected. As this region contains all those values of the...
13.2K
Predicting Reaction Outcomes02:24

Predicting Reaction Outcomes

Kinetics describes the rate and path by which a reaction occurs. In contrast, thermodynamics deals with state functions and describes the properties, behavior, and components of a system. It is not concerned with the path taken by the process and cannot address the rate at which a reaction occurs. Although it does provide information about what can happen during a reaction process, it does not describe the detailed steps of what appears on an atomic or a molecular level. On the other hand,...
10.3K