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Sufentanil Sublingual Tablet: A New Option for Acute Pain Management
Caitlin E Reardon1,2, Sandra L Kane-Gill1,2, Pamela L Smithburger1,2
1The University of Pittsburgh, Pittsburgh, PA, USA.
The Annals of Pharmacotherapy
|July 9, 2019
Summary
Sufentanil sublingual tablet (SST) is a safe and effective option for acute pain management when intravenous access is difficult. This opioid offers rapid and sustained analgesia, addressing unmet needs in various clinical settings.
Area of Science:
- Pharmacology and Therapeutics
- Pain Management
- Clinical Practice
Background:
- Parenteral opioids are standard for moderate to severe acute pain.
- Intravenous (IV) access can be challenging in certain patient populations and settings.
- Alternative routes of opioid administration are needed to address these limitations.
Purpose of the Study:
- To review the safety and efficacy of sufentanil sublingual tablet (SST).
- To determine the therapeutic role of SST for acute pain management in patients requiring parenteral opioids.
Main Methods:
- A comprehensive literature search of MEDLINE/PubMed from 2010 to April 2019 was conducted.
- Keywords included "sufentanil sublingual tablet," "sufentanil," "opioid," and "moderate to severe acute pain."
- English language articles evaluating SST pharmacology, pharmacokinetics, efficacy, and safety in humans were included.
Main Results:
- SST is FDA-approved and demonstrated safety and efficacy in medically supervised settings.
- Phase III trials showed a statistically significant reduction in pain intensity scores compared to placebo.
- SST provides rapid onset and sustained analgesia.
Conclusions:
- SST is a valuable option for patients needing parenteral opioids but lacking IV access or facing delays in obtaining it.
- Its utility extends to procedural pain, emergency departments, and battlefield scenarios.
- SST can also serve as an alternative during parenteral opioid shortages.
Keywords:
acute painopioid usepostsurgical pain managementsevere painsufentanilsufentanil sublingual tabletMore Related Videos
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