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Updated: Jan 22, 2026

Rat Model of Photochemically-Induced Posterior Ischemic Optic Neuropathy
Published on: November 29, 2015
Compressive optic neuropathy secondary to an allergic reaction to hyaluronidase
R Alcubierre1, B F Sanchez-Dalmau2, K Mousavi3
1Centre Ocular Quirúrgic de Sant Boi, Sant Boi de Llobregat, Barcelona, España; Departamento de Oftalmología, Hospital General de l'Hospitalet, Hospitalet de Llobregat, Barcelona, España.
Abstract:
A 58 year-old woman presented with severe chemosis and ophthalmoparesis on her left eye 8hours after uncomplicated cataract surgery under sub-tenon anaesthesia. Recovery of extrinsic motility was observed after corticosteroid and antihistamine treatment, but a non-haemorrhagic papillary oedema and a concentric defect of visual field were found. It progressed to papillary atrophy with preserved central vision, but with a significant visual field constriction. The aetiological study revealed an allergy to hyaluronidase that was used as adjuvant to the anaesthesia. This complication needs to be promptly diagnosed and treated, as the swelling of the orbital tissues can cause damage to the optic nerve.
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