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10:31
Diffuse Reflectance Infrared Spectroscopic Identification of Dispersant/Particle Bonding Mechanisms in Functional Inks
Published on: May 8, 2015
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Near-infrared spectroscopic applications in pharmaceutical particle technology
M Razuc1,2, A Grafia3, L Gallo2,3
1Instituto de Química del Sur (INQUISUR), Universidad Nacional del Sur (UNS)-CONICET , Bahía Blanca , Argentina.
Drug Development and Industrial Pharmacy
|July 9, 2019
Summary
Near-infrared spectroscopy (NIRS) is a key tool in pharmaceutical particle technology. This review highlights NIRS advancements for characterizing diverse materials and dosage forms, aiding formulation and process engineering.
Area of Science:
- Analytical Chemistry
- Pharmaceutical Technology
Background:
- Near-infrared spectroscopy (NIRS) is an established analytical technique within the pharmaceutical industry.
- Significant advancements have been made in applying NIRS for pharmaceutical analysis.
Purpose of the Study:
- To review the progress and applications of NIRS in pharmaceutical particle technology.
- To demonstrate the utility of NIRS for characterizing various pharmaceutical materials and dosage forms.
Main Methods:
- Review of literature and scientific publications on NIRS in pharmaceuticals.
- Analysis of spectral data to illustrate fundamental understanding.
- Discussion of sampling techniques and process monitoring applications.
Main Results:
- NIRS effectively characterizes active pharmaceutical ingredients, excipients, powders, and dosage forms.
- NIRS provides insights into mixing, tableting, and coating processes.
- Fundamental understanding of NIRS has been significantly enhanced.
Conclusions:
- NIRS is a valuable technique for pharmaceutical particle technology.
- NIRS supports product formulation and process engineering specialists.
- Continued development of NIRS methods offers further potential in pharmaceutical analysis.
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