[Allergies to non-betalactam antibiotics: a challenge in practice]

Allergies to non-betalactam antibiotics: a challenge in practice Abstract. The heterogeneous group of non-betalactam antibiotics can in part trigger very severe immunologically mediated hypersensitivity reactions. The risks are very differently distributed among the different representatives and a genetic predisposition to the development of Stevens-Johnson syndrome / toxic epidermal necrolysis or Drug rash with eosinophilia and systemic symptoms (DRESS syndrome) can be observed. Individual patient groups are particularly frequently affected, including patients with HIV or cystic fibrosis. In this overview, the individual drug groups and corresponding risk situations as well as the available diagnostic means are discussed.