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A Method for Measuring RNA N6-methyladenosine Modifications in Cells and Tissues
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A Method for Measuring RNA N6-methyladenosine Modifications in Cells and Tissues

Published on: December 5, 2016

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Regulation of Viral Infection by the RNA Modification N6-Methyladenosine

Graham D Williams1, Nandan S Gokhale1, Stacy M Horner1,2

  • 1Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina 27710, USA; email: graham.williams@duke.edu, nandan.gokhale@duke.edu, stacy.horner@duke.edu.

Annual Review of Virology
|July 9, 2019
PubMed

Insights

The RNA modification N6-methyladenosine (m6A) is crucial for viral infections and cellular immunity. This review details m6A

Area of Science:

  • Molecular Biology
  • Virology
  • Immunology

Background:

  • N6-methyladenosine (m6A) is a prevalent RNA modification impacting RNA biology.
  • m6A plays a significant role in viral life cycles and host responses to infection.

Purpose of the Study:

  • To review recent advancements in m6A detection techniques.
  • To summarize the cellular machinery involved in m6A regulation (writers, erasers, readers).
  • To elucidate the multifaceted roles of m6A in viral infections and immune responses.

Main Methods:

  • Review of recent literature on m6A modification and its role in viral infections.
  • Analysis of emerging techniques for studying m6A.
  • Synthesis of current understanding of m6A's impact on cellular and viral RNA.

Main Results:

  • m6A regulates fundamental aspects of RNA biology.
  • m6A influences innate and adaptive immune responses during viral infections.
  • Numerous roles of m6A in viral infection have been recently discovered.

Conclusions:

  • m6A is a key regulator in the interplay between viruses and host cells.
  • Further research is needed to fully uncover the functions of m6A during infection.
  • Understanding m6A dynamics offers potential therapeutic avenues.
Keywords:
DNA virusesN6-methyladenosineRNA modificationsRNA virusesinnate immunitym6Apost-transcriptional regulation

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