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MicroRNA-based potential diagnostic, prognostic and therapeutic applications in triple-negative breast cancer

Qian Tang1, Hu Ouyang1, Dongxiu He1,2

  • 1a Institute of Pharmacy and Pharmacology, University of South China , Hengyang , Hunan , China.

Artificial Cells, Nanomedicine, and Biotechnology
|July 10, 2019
PubMed

Insights

Triple-negative breast cancer (TNBC) shows poor prognosis. MicroRNAs (miRNAs) are key in TNBC development and progression, offering potential for new diagnostic and therapeutic strategies.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Triple-negative breast cancer (TNBC) presents a significant clinical challenge due to high recurrence rates and limited treatment options.
  • MicroRNAs (miRNAs) are critical regulators of gene expression involved in various cellular processes.
  • Emerging evidence highlights the crucial role of miRNAs in TNBC initiation, progression, and metastasis.

Purpose of the Study:

  • To review recent advancements in the application of microRNAs for triple-negative breast cancer.
  • To explore the potential of miRNAs in the diagnosis, treatment, and prognosis of TNBC.

Main Methods:

  • Literature review of recent studies on microRNAs and triple-negative breast cancer.
  • Analysis of miRNA involvement in TNBC pathogenesis.
  • Evaluation of miRNA-based diagnostic and therapeutic strategies.

Main Results:

  • MicroRNAs are implicated in the initiation, promotion, malignant conversion, progression, and metastasis of TNBC.
  • Specific miRNAs show potential as biomarkers for TNBC diagnosis and prognosis.
  • miRNA-based therapies are being investigated for their efficacy in treating TNBC.

Conclusions:

  • MicroRNAs represent a promising avenue for improving the diagnosis and treatment of triple-negative breast cancer.
  • Targeting miRNAs could offer novel therapeutic strategies to combat TNBC.
  • Further research into miRNA functions and applications is crucial for clinical translation in TNBC.
Keywords:
DiagnosismicroRNAprognosistreatmenttriple-negative breast cancer

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