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Published on: August 25, 2020
Helminths and Asthma: Risk and Protection
Jamille Souza Fernandes1, Luciana Santos Cardoso2, Paulo M Pitrez3
1Centro das Ciências Biológicas e da Saúde, Universidade Federal do Oeste da Bahia, Rua Bertioga, n° 892, Morada Nobre, Barreiras, Bahia 47810-059, Brazil; ProAR - Universidade Federal da Bahia, Salvador, Bahia, Brazil.
Abstract:
Helminth infections may inhibit the development of allergic diseases, including asthma. On the other hand, some helminth species may induce or worsen symptoms of asthma. This article discusses the impact of helminth infections on asthma as well as the potencial of helminth-derived molecules with regulatory characteristics in the prevention or treatment of this disease. The ability to induce regulation has been observed in animal models of asthma or cells of asthmatic individuals in vitro. Potential future clinical applications of helminth antigens or infection for prevention of asthma merit further translational research.
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