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A Rat Orthotopic Renal Transplantation Model for Renal Allograft Rejection
Published on: February 2, 2022
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Urinary CXCL9 and CXCL10 Levels and Acute Renal Graft Rejection
H S Ciftci1, T Tefik2, M K Savran3
1Department of Medical Biology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
International Journal of Organ Transplantation Medicine
|July 10, 2019
Summary
Urinary CXCL9 and CXCL10 levels show promise in predicting T cell-mediated rejection after kidney transplants. Measuring these chemokines in urine may offer a new diagnostic tool for early detection of transplant rejection.
Area of Science:
- Nephrology
- Immunology
- Transplantation Science
Background:
- Monitoring serum chemokines CXCL9 and CXCL10 is a potential non-invasive method for detecting transplant rejection.
- Early detection of renal transplant rejection is crucial for graft survival.
Purpose of the Study:
- To investigate the relationship between urinary levels of CXCL9 and CXCL10 and graft function following renal transplantation.
- To assess the predictive value of urinary chemokines for renal transplant rejection.
Main Methods:
- A study involving 75 living-related donor renal transplant recipients.
- Urinary chemokine levels (CXCL9 and CXCL10) were measured pre-operatively and at multiple time points post-transplantation using enzyme-linked immunosorbent assay.
- Clinical variables and biopsy-proven rejection were monitored throughout the follow-up period.
Main Results:
- Urinary CXCL9 and CXCL10 levels were significantly higher in patients with biopsy-proven rejection compared to those without rejection, particularly on post-operative days 1 and 7, and at the time of rejection.
- Serum creatinine levels correlated strongly with urinary CXCL9 and CXCL10 levels at the time of rejection.
- In T cell-mediated rejections, urinary CXCL10 levels increased significantly.
Conclusions:
- Urinary CXCL9 and CXCL10 levels may serve as predictive markers for T cell-mediated rejection in the early post-transplantation period.
- Measuring urinary CXCL9 and CXCL10 offers a potential additional diagnostic tool for identifying renal transplant rejection.
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