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Detection of Targetable Alterations in Non-small Cell Lung Cancer using Next-generation Sequencing
Published on: October 10, 2025
363
Changes in store for early-stage non-small cell lung cancer
Jason E Sandler1, Angelica D'Aiello1, Balazs Halmos2
1Department of Medicine, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY, USA.
Journal of Thoracic Disease
|July 10, 2019
Summary
New treatments are emerging for early-stage non-small cell lung cancer (NSCLC). While biomarker-targeted therapies and immunotherapies show promise, ongoing trials aim to improve curative options for resected NSCLC patients.
Area of Science:
- Oncology
- Pulmonology
- Medical Research
Background:
- Advanced non-small cell lung cancer (NSCLC) management has advanced significantly with targeted therapies and immunotherapies.
- Treatment for early-stage (IB-IIIA) resected NSCLC has seen limited progress since the advent of adjuvant chemotherapy 20 years ago.
- There is a critical need for improved curative strategies in early-stage NSCLC.
Purpose of the Study:
- To review recent data and ongoing studies for early-stage NSCLC treatment.
- To evaluate the potential of tyrosine kinase inhibitors (TKIs) and immunotherapies in early-stage NSCLC.
- To anticipate future advances in the curative treatment of early-stage NSCLC.
Main Methods:
- Review of recently presented data in early-stage NSCLC.
- Analysis of ongoing and planned clinical trials, including Phase III studies.
- Focus on biomarker-driven therapeutic approaches and immunotherapy strategies.
Main Results:
- Investigative efforts with TKIs in early-stage NSCLC have produced mixed results.
- Innovative immunotherapy studies, particularly in the neoadjuvant setting, have shown promising outcomes.
- Numerous pivotal neoadjuvant and adjuvant immunotherapy trials are currently in progress.
Conclusions:
- Future advances in early-stage NSCLC treatment are anticipated due to improved trial designs and biomarker focus.
- Biomarker-driven targeted therapies and immunotherapies represent promising avenues for curative treatment.
- Ongoing and planned studies are expected to significantly enhance the optimal management of early-stage NSCLC.
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