Cu-Catalyzed highly selective reductive functionalization of 1,3-diene using H2O as a stoichiometric hydrogen atom
Qifan Li1, Xiaoyang Jiao1, Mimi Xing1
1Department of Chemistry, Tianjin Key Laboratory of Molecular Optoelectronic Science, School of Sciences, Institute of Molecular Plus, Tianjin University, Weijin Rd. 92, Tianjin 300072, China. chunzhang@tju.edu.cn.
Abstract:
A copper-catalyzed highly regio- and diastereo-selective reductive reaction of terminal 1,3-diene with water and aldehyde has been developed. This chemistry afforded a product containing a terminal alkenyl group, which is a versatile kind of precursor for organic synthesis, with the scope for various substrates. The present reaction system could realize the catalytic transfer of hydrogen to diene using water as a stoichiometric H atom donor. In this transformation, B2Pin2, a mild and practical kind of reductant was used as the mediator. The reaction pathway of this practical strategy was illustrated by a control experiment.
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