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SyMRI detects delayed myelination in preterm neonates.

Victor Schmidbauer1, Gudrun Geisl1, Mariana Diogo1

  • 1Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.

European Radiology
|July 10, 2019
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Summary

SyMRI software enables faster and more sensitive assessment of neonatal brain myelination. This advanced MRI technique visually detects delayed myelination in preterm infants, outperforming conventional methods.

Keywords:
BrainGestational ageMagnetic resonance imagingNewbornSoftware

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Area of Science:

  • Neonatal neuroimaging
  • Radiology
  • Biomedical engineering

Background:

  • Accurate assessment of brain myelination is crucial for evaluating neonatal neurodevelopment.
  • Conventional MRI sequences can be time-consuming and may lack sensitivity in detecting subtle myelination differences.
  • The multi-dynamic multi-echo (MDME)-FLAIR sequence offers potential for improved tissue characterization.

Purpose of the Study:

  • To evaluate the applicability of SyMRI software for assessing myelination in preterm and term-born neonates.
  • To compare the performance of SyMRI with conventional MRI techniques in myelination assessment.
  • To determine if SyMRI can detect delayed myelination in preterm infants.

Main Methods:

  • Utilized SyMRI software for post-processing of a single MDME-FLAIR sequence acquisition (5 min 24 s).
  • Assessed myelination by scoring seven brain regions on SyMRI-generated quantitative T1-/T2-maps.
  • Compared SyMRI-based scores with those from conventional T1-/T2-weighted MRI and analyzed using ANCOVA with gestational age at MRI as a covariate.

Main Results:

  • SyMRI acquisitions were successful in 83.3% of 30 neonates.
  • SyMRI-based myelination scores were significantly lower in preterm compared to term-born neonates (p<0.05 for both T1 and T2).
  • SyMRI scores positively correlated with gestational age at MRI, while conventional MRI scores did not.

Conclusions:

  • SyMRI is a promising MR technique for neonatal brain imaging, offering a time-saving approach.
  • SyMRI provides superior visual detection of delayed myelination in preterm neonates compared to conventional MRI.
  • SyMRI enables faster and more sensitive assessment of myelination in neonates.