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Variable loss of CD30 expression by immunohistochemistry in recurrent cutaneous CD30+ lymphoid neoplasms treated with

Amrita Goyal1, Sanjay Patel2, Kavita Goyal1

  • 1Department of Dermatology, University of Minnesota, Minneapolis, Minnesota.

Journal of Cutaneous Pathology
|July 10, 2019
PubMed
Abstract

Insights

Brentuximab vedotin treatment can lead to CD30 antigen loss in recurrent CD30+ neoplasms. This antigen loss may affect treatment efficacy and necessitates careful monitoring of persistent disease.

Area of Science:

  • Oncology
  • Immunotherapy
  • Dermatology

Background:

  • Brentuximab vedotin is an anti-CD30 antibody-drug conjugate used for CD30+ neoplasms.
  • Antigen loss is a known issue with antibody therapies, such as anti-CD20 rituximab.

Observation:

  • This study investigated antigen loss in nine patients with recurrent cutaneous CD30+ lymphoid neoplasms treated with brentuximab vedotin.
  • The cases included mycosis fungoides, unspecified cutaneous T-cell lymphoma, and anaplastic large cell lymphoma.

Findings:

  • Seven out of nine patients showed decreased CD30 expression after brentuximab vedotin therapy.
  • Pre-treatment CD30 expression averaged 50.0%, decreasing to 14.5% at recurrence (P = 0.003).

Implications:

  • CD30 positivity can be variable in recurrent CD30+ neoplasms post-brentuximab vedotin treatment.
  • Awareness of antigen loss is crucial; multiple biopsies and molecular diagnostics are recommended for persistent disease.
Keywords:
CD30+ cutaneous T-cell lymphomaanaplastic large cell lymphomabrentuximabloss of CD30mycosis fungoides

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