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Rhodium(II)-Catalyzed Dehydrogenative Silylation of Biaryl-Type Monophosphines with Hydrosilanes
Dingyi Wang1, Yunfei Zhao1, Chengkai Yuan1
1State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210093, China.
Abstract:
A rhodium-catalyzed system is introduced for in situ modification of biaryl-type monophosphines with hydrosilanes through a PIII -chelation-assisted dehydrogenative silylation reaction. A series of ligands containing silyl groups with different steric and electronic properties were obtained with excellent regioselectivities. This method offers many advantages, including the use of commercially available phosphines, no requirement for an external ligand or oxidant, a broader substrate scope, high efficiency, and access to a single regioisomer. Based on the outstanding properties of the parent scaffolds, the silyl-substituted phosphines serve as excellent ligands in Pd-catalyzed asymmetric Suzuki coupling reactions.
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