Related Experiment Video
Updated: Jan 22, 2026
Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
Published on: April 23, 2021
Comparing model-based cerebrovascular physiomarkers with DTI biomarkers in MCI patients
Vasilis Z Marmarelis1, Dae C Shin2, Takashi Tarumi3,4
1Department of Biomedical Engineering, University of Southern California, Los Angeles, California.
Objective:
To compare the novel model-based hemodynamic physiomarker of Dynamic Vasomotor Reactivity (DVR) with biomarkers based on Diffusion Tensor Imaging (DTI) and some widely used neurocognitive scores in terms of their ability to delineate patients with amnestic Mild Cognitive Impairment (MCI) from age-matched cognitively normal controls.
Materials & Methods:
The model-based DVR and MRI-based DTI markers were obtained from 36 patients with amnestic MCI and 16 age-matched controls without cognitive impairment, for whom widely used neurocognitive scores were available. These markers and scores were subsequently compared in terms of statistical delineation between patients and controls.
Results:
It was found that statistically significant delineation between MCI patients and controls was comparable for DVR or DTI markers (p < 0.01). The performance of both types of markers was consistent with the scores of some (but not all) widely used neurocognitive tests.
Conclusion:
Since DTI offers a measure of cerebral white matter integrity, the results suggest that the model-based hemodynamic marker of DVR may correlate with cognitive impairment due to white matter lesions. This finding is consistent with the hypothesis that dysregulation of cerebral microcirculation may be an early cause of cognitive impairment, which has been recently corroborated by several studies.
Related Concept Videos
02:26Comparing Copy Number Variations and SNPs
Copy number variations or CNVs are the structural variations that cover more than 1kb of DNA sequence. The single nucleotide polymorphism (SNP), on the other hand, is a single nucleotide change or a point mutation that is found in more than 1%...
01:20Comparing the Survival Analysis of Two or More Groups
01:09Comparing Experimental Results: Student's t-Test
02:24Comparative Excretory Systems
02:16Comparing Mitochondrial, Chloroplast, and Prokaryotic Genomes
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...