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Rotation of Asymmetric Top01:11

Rotation of Asymmetric Top

1.5K
By definition, a spherically symmetric body has the same moment of inertia about any axis passing through its center of mass. This situation changes if there is no spherical symmetry. Since most rigid bodies are not spherically symmetric, these require special treatment.
The relationship between the angular momentum of any rigid body and its angular velocity, both of which are vectors, involves the moment of inertia. The moment of inertia is a scalar quantity only for spherically symmetric...
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Streamlines, Streaklines, and Pathlines01:18

Streamlines, Streaklines, and Pathlines

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A streamline represents the trajectory that is always tangent to the fluid's velocity vector at any given point. The velocity of a fluid particle is always directed along the streamline, ensuring the particle continuously follows the streamline's path. Streamlines are particularly useful for visualizing the overall direction of flow in a fluid system, and they provide an instantaneous representation of the flow's velocity field. In steady flow, where conditions do not change over...
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Asymmetric Lipid Bilayer01:35

Asymmetric Lipid Bilayer

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Biological membranes show uneven distribution of different types of lipids in the inner and outer layers, resulting in transverse asymmetric membranes. The treatment of the erythrocyte membrane with the enzyme phospholipase confirmed the asymmetric nature of the lipid bilayer. The enzyme hydrolyzes lipids into fatty acids and hydrophilic groups. The phospholipase acts only on the outer layer of the membrane, while the inner layer remains intact. The phospholipase treatment resulted in 80%...
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Reduction of Alkenes: Asymmetric Catalytic Hydrogenation02:17

Reduction of Alkenes: Asymmetric Catalytic Hydrogenation

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Catalytic hydrogenation of alkenes is a transition-metal catalyzed reduction of the double bond using molecular hydrogen to give alkanes. The mode of hydrogen addition follows syn stereochemistry.
The metal catalyst used can be either heterogeneous or homogeneous. When hydrogenation of an alkene generates a chiral center, a pair of enantiomeric products is expected to form. However, an enantiomeric excess of one of the products can be facilitated using an enantioselective reaction or an...
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Bernoulli's Equation for Flow Along a Streamline01:30

Bernoulli's Equation for Flow Along a Streamline

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Bernoulli's equation relates the energy conservation in a fluid moving along a streamline. The equation applies to incompressible and inviscid fluids under steady flow. For such a flow, Newton's second law is applied to a small fluid element, which experiences forces due to pressure differences, gravity, and velocity variations. The force balance leads to the following form of Bernoulli's equation:
1.5K
Reaction Rate02:53

Reaction Rate

62.5K
The rate of reaction is the change in the amount of a reactant or product per unit time. Reaction rates are therefore determined by measuring the time dependence of some property that can be related to reactant or product amounts. Rates of reactions that consume or produce gaseous substances, for example, are conveniently determined by measuring changes in volume or pressure.
The mathematical representation of the change in the concentration of reactants and products, over time, is the rate...
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Related Experiment Video

Updated: Jan 22, 2026

Asymmetric Walkway: A Novel Behavioral Assay for Studying Asymmetric Locomotion
08:19

Asymmetric Walkway: A Novel Behavioral Assay for Studying Asymmetric Locomotion

Published on: January 15, 2016

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Streamlined Asymmetric Reaction Development: A Case Study with Isatins.

F Yushra Thanzeel1, Kaluvu Balaraman1, Christian Wolf1

  • 1Department of Chemistry, Georgetown University, 37th and O Streets, Washington, DC, 20057, USA.

Chemistry (Weinheim an Der Bergstrasse, Germany)
|July 10, 2019
PubMed
Summary
This summary is machine-generated.

Developing asymmetric reactions rapidly is now possible using a streamlined high-throughput screening (HTS) strategy. This method, demonstrated with asymmetric allylation of isatins, significantly reduces time and effort for synthetic chemists.

Keywords:
UV spectroscopyasymmetric reaction developmentcircular dichroismhigh throughput screeningisatins

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Area of Science:

  • Organic Chemistry
  • Synthetic Chemistry
  • Catalysis

Background:

  • Achieving rapid asymmetric reaction development has been a long-standing goal in synthetic chemistry.
  • Traditional methods often involve lengthy optimization processes and extensive preliminary work.

Purpose of the Study:

  • To demonstrate a highly efficient and streamlined screening strategy for rapid asymmetric reaction development.
  • To showcase the feasibility of developing asymmetric reactions within days using high-throughput screening (HTS).

Main Methods:

  • A high-throughput screening (HTS) method utilizing fast optical UV/CD analysis of crude reaction mixtures (≈3 mg scale).
  • The strategy obviates the need for product isolation and reference compounds, reducing analysis time.
  • Screening of 54 asymmetric allylations of nine different isatins across six solvents was performed by a single operator in under 20 work hours.

Main Results:

  • The HTS strategy enabled rapid development of asymmetric allylation reactions.
  • Optimized conditions led to the upscale synthesis of two representative 3-allyl-3-hydroxyisatins with high yields (98-99%) and enantioselectivity (91-94% ee).

Conclusions:

  • This streamlined HTS strategy makes rapid asymmetric reaction development feasible.
  • The approach significantly reduces preliminary work and analysis time, with potential for automation.
  • The method is effective for developing efficient catalytic systems for asymmetric synthesis.