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Measuring Reaction Rates

Measuring Reaction Rates

Polarimetry finds application in chemical kinetics to measure the concentration and reaction kinetics of optically active substances during a chemical reaction. Optically active substances have the capability of rotating the plane of polarization of linearly polarized light passing through them—a feature called optical rotation. Optical activity is attributed to the molecular structure of substances. Normal monochromatic light is unpolarized and possesses oscillations of the electrical...

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Updated: May 20, 2025

Optimization of the Ugi Reaction Using Parallel Synthesis and Automated Liquid Handling

Optimization of the Ugi Reaction Using Parallel Synthesis and Automated Liquid Handling

Published on: November 11, 2008

Integrating Catalysis and Analysis: Accelerated Asymmetric Reaction Development With a Multitasking Reactivity

F Safia Kariapper¹, Maria Bouda¹, Christian Wolf¹

¹Department of Chemistry, Georgetown University, 37th & O Street, Washington, DC, 20057, USA.

Chemistry (Weinheim an Der Bergstrasse, Germany)

|May 9, 2025

Summary

This study introduces a novel method for developing asymmetric organocatalytic reactions using isatin. This approach enables rapid, chromatography-free screening for efficient synthesis of chiral products from primary amines.

Keywords:

asymmetric catalysis chiroptical sensing circular dichroism high‐throughput screening reaction optimization

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Optimization of Radiochemical Reactions using Droplet Arrays

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Last Updated: May 20, 2025

Optimization of the Ugi Reaction Using Parallel Synthesis and Automated Liquid Handling

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Published on: November 11, 2008

Real-time Monitoring of Reactions Performed Using Continuous-flow Processing: The Preparation of 3-Acetylcoumarin as an Example

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Optimization of Radiochemical Reactions using Droplet Arrays

Optimization of Radiochemical Reactions using Droplet Arrays

Published on: February 12, 2021

Area of Science:

Organic Chemistry
Asymmetric Synthesis
Catalysis

Background:

Developing efficient asymmetric reactions is crucial for synthesizing chiral molecules.
Traditional reaction optimization is often time-consuming and resource-intensive.
High-throughput screening methods can accelerate catalyst and reaction condition discovery.

Purpose of the Study:

To develop a high-throughput method for asymmetric organocatalytic Michael addition.
To utilize a multitasking reagent for streamlined reaction screening and analysis.
To demonstrate increased speed, reduced cost, and minimized waste in reaction development.

Main Methods:

Employed isatin as a protecting group, reactivity Umpolung reagent, and chiroptical reporter.
Utilized UV and circular dichroism (CD) spectroscopy for on-the-fly analysis.
Performed parallel screening of numerous reaction conditions without chromatography.

Main Results:

Identified a catalytic procedure for converting primary amines to chiral products with high yields and enantioselectivities (ee's).
Demonstrated the recyclability and quantitative recovery of the isatin reagent.
Achieved chromatography-free, parallel screening of up to one hundred reaction conditions.

Conclusions:

Isatin serves as a versatile multitasking reagent for efficient asymmetric reaction development.
Chiroptical high-throughput screening significantly enhances method development speed.
This integrated approach reduces cost and waste compared to conventional optimization workflows.