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Updated: Jan 22, 2026

Using the Open-Source MALDI TOF-MS IDBac Pipeline for Analysis of Microbial Protein and Specialized Metabolite Data
Published on: May 15, 2019
Anthraquinone-Based Specialized Metabolites from Rhizomes of Bulbine natalensis
Ji-Yeong Bae1, Zulfiqar Ali1, Yan-Hong Wang1
1National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy , University of Mississippi , University , Mississippi 38677 , United States.
Abstract:
The rhizomes of Bulbine natalensis furnished six previously unreported anthraquinone derivatives (1-6), together with eight known specialized metabolites. Their structures were determined by interpretation of 1D and 2D NMR and HRESIMS data. The absolute configurations of compounds 1-6 were determined by specific rotation and circular dichroism experiments. The isolated compounds were evaluated for antimicrobial activities, and compound 1 was found to be a moderate inhibitor (IC50 0.02 μM) against methicillin-resistant Staphylococcus aureus (MRSA).
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