Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Group Polarization01:01

Group Polarization

38.4K
Group polarization is the strengthening of an original group attitude following the discussion of views within a group (Teger & Pruitt, 1967). That is, if a group initially favors a viewpoint, after discussion the group consensus is likely a stronger endorsement of the viewpoint. Conversely, if the group was initially opposed to a viewpoint, group discussion would likely lead to stronger opposition.
38.4K
Molecular Shape and Polarity03:37

Molecular Shape and Polarity

74.6K
Dipole Moment of a Molecule
74.6K
Cell Polarization by Rho Proteins01:21

Cell Polarization by Rho Proteins

3.6K
Cell polarity is the asymmetric distribution of cellular and membrane components, making one side of the cell different from the other. This polarity is essential to many processes such as embryogenesis, axon migration, glucose transport across epithelial cells, and directional cell migration. A migrating cell responds to intracellular or extracellular signals via molecular cascades that reorganize the actin cytoskeleton to establish this polarity. In these cells, the Rho family proteins Cdc42,...
3.6K
Polarity of the Cytoskeleton01:18

Polarity of the Cytoskeleton

24.3K
The intrinsic polarity of cells can be primarily attributed to two factors- i) the asymmetric accumulation of mobile components such are regulatory molecules and subcellular components across the cell and ii) the orientation of polar cytoskeletal filaments that make up the cytoskeletal networks, specifically microfilaments, and microtubules arranged along the axis of polarity. Interactions between the cytoskeletal filaments are crucial for the establishment and maintenance of the polar nature...
24.3K
Bond Polarity, Dipole Moment, and Percent Ionic Character02:48

Bond Polarity, Dipole Moment, and Percent Ionic Character

35.3K
Bond Polarity
35.3K
Polar Covalent Bonds02:24

Polar Covalent Bonds

28.1K
Covalent bonds are formed between two atoms when both have similar tendencies to attract electrons to themselves (i.e., when both atoms have identical or fairly similar ionization energies and electron affinities). Nonmetal atoms frequently form covalent bonds with other nonmetal atoms. For example, the hydrogen molecule, H2, contains a covalent bond between its two hydrogen atoms. When two separate hydrogen atoms with a particular potential energy approach each other, their valence orbitals...
28.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

LGL-1 and the RhoGAP protein PAC-1 redundantly polarize the Caenorhabditis elegans embryonic epidermis.

The Journal of cell biology·2026
Same author

LGL-1 and the RhoGAP protein PAC-1 redundantly polarize the <i>C. elegans</i> embryonic epidermis.

bioRxiv : the preprint server for biology·2026
Same author

Engineered chromatin readers track damaged chromatin dynamics in live cells and animals.

Nature communications·2025
Same author

The First of Us: <i>Ophiocordyceps</i> use a novel scramblase-binding peptide to manipulate zombie ants.

bioRxiv : the preprint server for biology·2025
Same author

SUMO-mediated regulation of H3K4me3 reader SET-26 controls germline development in C. elegans.

PLoS biology·2025
Same author

Intermediate filament network perturbation in the

eLife·2023
Same journal

Hunting ecology predicts eye arrangements in the modular visual system of spiders.

Current biology : CB·2026
Same journal

Sub-second fluctuations between top-down and bottom-up modes distinguish diverse human brain states.

Current biology : CB·2026
Same journal

Queen bees offload pesticide burden to eggs when social buffering is overwhelmed.

Current biology : CB·2026
Same journal

Pitch selectivity in ferret auditory cortex.

Current biology : CB·2026
Same journal

A cell size-dependent competition between geometry and polarity governs nuclear and spindle positioning in early embryos.

Current biology : CB·2026
Same journal

Trophic cascades drive sustainability in the agricultural heritage rice-fish coculture system.

Current biology : CB·2026
See all related articles

Related Experiment Video

Updated: Jan 22, 2026

Human ES cells: Starting Culture from Frozen Cells
02:47

Human ES cells: Starting Culture from Frozen Cells

Published on: November 9, 2006

12.7K

Cell Polarity: Getting the PARty Started.

Mike Boxem1, Sander van den Heuvel1

  • 1Developmental Biology, Department of Biology, Faculty of Science, Utrecht University, Padualaan 8, 3584 CH, Utrecht, The Netherlands.

Current Biology : CB
|July 10, 2019
PubMed
Summary
This summary is machine-generated.

Cell polarity timing is regulated by the PAR system in C. elegans. Inhibiting key proteins like AIR-1 (aurora A) and PLK-1 (polo kinase) prevents premature cell polarization during development.

More Related Videos

Analyzing the Function of Small GTPases by Microinjection of Plasmids into Polarized Epithelial Cells
09:38

Analyzing the Function of Small GTPases by Microinjection of Plasmids into Polarized Epithelial Cells

Published on: May 31, 2011

11.9K
Evaluation of Planar-Cell-Polarity Phenotypes in Ciliopathy Mouse Mutant Cochlea
07:07

Evaluation of Planar-Cell-Polarity Phenotypes in Ciliopathy Mouse Mutant Cochlea

Published on: February 21, 2016

11.0K

Related Experiment Videos

Last Updated: Jan 22, 2026

Human ES cells: Starting Culture from Frozen Cells
02:47

Human ES cells: Starting Culture from Frozen Cells

Published on: November 9, 2006

12.7K
Analyzing the Function of Small GTPases by Microinjection of Plasmids into Polarized Epithelial Cells
09:38

Analyzing the Function of Small GTPases by Microinjection of Plasmids into Polarized Epithelial Cells

Published on: May 31, 2011

11.9K
Evaluation of Planar-Cell-Polarity Phenotypes in Ciliopathy Mouse Mutant Cochlea
07:07

Evaluation of Planar-Cell-Polarity Phenotypes in Ciliopathy Mouse Mutant Cochlea

Published on: February 21, 2016

11.0K

Area of Science:

  • Cell biology
  • Developmental biology
  • Genetics

Background:

  • Establishing cell polarity is crucial for development.
  • The precise timing of polarity establishment is not well understood.
  • The PAR polarity system plays a key role in this process.

Purpose of the Study:

  • To investigate the mechanisms regulating the timing of polarity establishment.
  • To understand how the PAR polarity system becomes competent to polarize.
  • To identify factors that prevent premature polarization.

Main Methods:

  • Utilized the model organism Caenorhabditis elegans.
  • Investigated the PAR polarity system.
  • Inhibited membrane localization of anterior PAR proteins, specifically AIR-1 (aurora A) and PLK-1 (polo kinase).

Main Results:

  • The PAR polarity system undergoes significant reconfiguration before achieving polarization competence.
  • Inhibiting the membrane localization of AIR-1 and PLK-1 effectively prevents premature polarization.
  • This suggests a regulatory role for these proteins in controlling the timing of polarity establishment.

Conclusions:

  • The timing of polarity establishment is actively regulated.
  • AIR-1 (aurora A) and PLK-1 (polo kinase) are critical regulators preventing premature polarization.
  • Reconfiguration of the PAR system precedes developmental polarization competence.