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Related Concept Videos

What is Homeostasis?01:16

What is Homeostasis?

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Maintaining homeostasis requires that the body continuously maintain its internal conditions. Each physiological condition has a particular set point, from body temperature to blood pressure to levels of certain nutrients. A set point is the physiological value around which the normal range fluctuates. A normal range is a restricted set of values that is optimally healthful and stable. For example, the set point for normal human body temperature is approximately 37°C (98.6°F).
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pH Homeostasis01:31

pH Homeostasis

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Acid-base homeostasis is essential for maintaining normal physiological activities in humans. The pH of various body fluids is strictly regulated because it is critical for the optimal activity of enzymes involved in metabolic reactions. Enzymes are basically proteins, so, any significant change in pH can affect their structure and activity. In humans, pH is regulated using three primary mechanisms— chemical buffer systems, respiratory regulation, and renal regulation.
Respiratory...
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Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
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Voltage01:13

Voltage

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The movement of electrons in a conductor requires some form of energy or work, usually provided by an external force, like a battery. This force is called the electromotive force or voltage. The voltage between two points, referred to as points "a" and "b," in an electric circuit is the energy (or work) needed to move a unit charge from point "a" to point "b," and this relationship is expressed mathematically as
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Voltage Dividers01:14

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In electrical circuits, resistors can be connected in series, sequentially linked one after the other. In a series configuration, the same current flows through each resistor. Ohm's law is a fundamental principle to understand the behavior of resistors in series. It expresses the voltage across these resistors in terms of the current and resistance.
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Three-Phase Voltages01:30

Three-Phase Voltages

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A three-phase generator produces three voltages that are equal in magnitude but have a phase difference of 120 degrees. This identical magnitude and equal phase separated voltages are known as the balanced voltages and help to minimize power loss while ensuring a steady delivery of energy to connected loads. As voltage sources in a three-phase system can be configured in a wye or a delta formation, the loads connected to these systems can also be arranged in either configuration. This...
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Related Experiment Video

Updated: Jan 22, 2026

Optical Imaging of Neurons in the Crab Stomatogastric Ganglion with Voltage-sensitive Dyes
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Optical Imaging of Neurons in the Crab Stomatogastric Ganglion with Voltage-sensitive Dyes

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Neuronal Homeostasis: Voltage Brings It All Together.

Jorge Golowasch1

  • 1Federated Department of Biological Sciences, New Jersey Institute of Technology & Rutgers University-Newark, Institute for Brain and Neuroscience Research, Newark, NJ 07102, USA.

Current Biology : CB
|July 10, 2019
PubMed
Summary

Neurons maintain stable activity patterns by regulating variable ion channel conductances. This essential control relies heavily on the neuron

Area of Science:

  • Neuroscience
  • Computational Neuroscience

Background:

  • Neurons exhibit complex electrical activity governed by numerous ionic currents and conductance states.
  • Maintaining stable neuronal firing patterns despite this inherent variability is crucial for proper brain function.

Purpose of the Study:

  • To investigate the mechanisms by which neurons regulate the variability of their activity.
  • To determine the role of neuronal activity itself in controlling conductance variability.

Main Methods:

  • Analysis of ionic current dynamics in computational neuron models.
  • Simulations exploring the interplay between conductance states and neuronal firing patterns.

Main Results:

  • Neuronal activity patterns are generated by a combination of multiple ionic currents.

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Profiling Voltage-gated Potassium Channel mRNA Expression in Nigral Neurons using Single-cell RT-PCR Techniques
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Profiling Voltage-gated Potassium Channel mRNA Expression in Nigral Neurons using Single-cell RT-PCR Techniques

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Voltage-sensitive Dye Recording from Axons, Dendrites and Dendritic Spines of Individual Neurons in Brain Slices
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  • The regulation of variable conductance levels is intrinsically linked to the neuron's own activity.
  • Self-regulation mechanisms prevent uncontrolled variability in neuronal function.

    • Conclusions:

    • Neuronal activity itself is the primary factor in controlling the variability of ionic conductances.
    • This self-regulatory process ensures the stability and reliability of neural signaling.
    • Understanding this mechanism is key to comprehending neural computation and disorders.